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Early hyperthyroidism alters the distribution of mossy fibres in the rat hippocampus

Nature volume 268, pages 335–337 (1977)Cite this article

Abstract

DAILY injections of thyroid hormone initiated on the day of birth and continued for several weeks, significantly accelerate the differentiation of cerebellar granule cells1–3, which are formed after birth4. Since most of the hippocampal granule cells are also generated postnatally, early hyperthyroidism was chosen as a means of studying possible mechanisms involved in the formation of synapses between granule cell axons (mossy fibres) and pyramidal cell dendrites. This note provides the light microscopic demonstration, with the Timm silver sulphide method5, that hyperthyroidism in the rat consistently results in the formation of ectopic hippocampal mossy fibres. Electron microscopic and Golgi studies are in progress and will be published separately.

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Authors and Affiliations

  1. Laboratory of Neuromorphology, Department of Biobehavioral Sciences, The University of Connecticut, Storrs, Connecticut, 06268

    JEAN M. LAUDER & ENRICO MUGNAINI

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  1. JEAN M. LAUDER
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  2. ENRICO MUGNAINI
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LAUDER, J., MUGNAINI, E. Early hyperthyroidism alters the distribution of mossy fibres in the rat hippocampus. Nature 268, 335–337 (1977). https://doi.org/10.1038/268335a0

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