Abstract
ALTHOUGH recovery of function following brain damage has long been known to occur, the mechanisms involved are not completely understood1. Of relevance to this problem are reports of pharmacological facilitation of recovery from brain damage in humans2 and from experimentally-induced nervous system lesions in animals3–9. We have previously reported that L-dopa injections produce a dramatic and apparently permanent abolition of the hyper-reactivity or rage syndrome that results from surgical damage to the septal nuclei of the rat forebrain10. Independent confirmation of this finding has also appeared11. We report here that other dopamine agonists share this ability to attenuate or abolish the septal rage syndrome (SRS).
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References
Stein, D. G., Rosen, J. J. & Butters, N. (eds) Plasticity and Recovery of Function in the central Nervous System (Academic, New York, 1974).
Luria, A., Naydin, V., Tsvetkova, L. & Vinarskaya, E. in Handbook of Clinical Neurology (eds Vinkin, R. J. & Bruyn, G. W.) 3 (North Holland, Amsterdam, 1968).
Wolf, A. J. nerv. ment. Dis. 92, 614–622 (1940).
Watson, C. & Kennard, M. J. Neurophysiol. 8, 221–231 (1945).
Mailing, H. & Acheson, G. J. Neurophysiol. 9, 379–386 (1946).
Braun, J. J., Meyer, P. M. & Meyer, D. R. J. comp. Physiol. Psychol. 61, 79–82 (1966).
Cole, D., Sullins, W. & Isaac, W. Psychopharmacologia 11, 311–316 (1967).
Berger, B., Wise, C. & Stein, L. Science 172, 281–284 (1971).
Dominguez, M. & Longo, V. Physiol. Behav. 5, 607–610 (1970).
Marotta, R. F., Potegal, M., Gardner, E. L. & Glusman, M. M. Am. Psychological Ass. Chicago, (1975).
Gage, F. H. & Olton, D. S. Behav. Biol. 17, 213–218 (1976).
Brady, J. B. & Nauta, W. J. H. J. comp. Physiol. Psychol. 46, 339–346 (1953).
King, F. J. nerv. ment. Dis. 126, 57–63 (1958).
Ungerstedt, U. Acta physiol. scand. Suppl. 367, 69–93 (1971).
Costall, B. & Naylor, R. J. Eur: J. Pharmac. 24, 8–24 (1973).
Cools, A. R. & Van Rossum, J. M. Psychopharmacologia 45, 243–254 (1976).
Raitt, J., Nelson, J. & Lye, A. Br. J. Pharmac. 17, 473–478 (1961).
Cytawa, J. & Kutulas, G. Psychopharmacologia 27, 389–392 (1972).
Stark, P. & Henderson, J. Neuropharmacology 11, 839–841 (1972).
Loizzo, A. & Massotti, M. Pharmac. Biochem. Behav. 1, 367–370 (1973).
Welch, B. L. & Welch, A. S. J. Pharm. Pharmac. 20, 244–246 (1968).
Brody, J. Psychopharmacologia 17, 14–33 (1970).
Gal, E. M. in Serotonin and Behavior (eds Barchas, J. D. & Usdin, E.) (Academic, New York, 1973).
Glusman, M. Res. Publ. Ass. Res. nerv. ment. Dis. 52, 52–92 (1974).
Rosner, B. S. in Plasticity and Recovery of Function in the Central Nervous System (eds Stein, D. G., Rosen, J. J. & Butters, N.) (Academic, New York, 1974).
Brownstein, M., Saavedra, J. M. & Palkovits, M. Brain Res. 79, 431–436 (1974).
Lindvall, D. & Bjorklund, A. Acta physiol. scand. Suppl. 412, 1–48 (1974).
Powell, P. S., Cowan, W. M. & Raisnian, G. J. Anat. 99, 791–813 (1965).
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MAROTTA, R., LOGAN, N., POTEGAL, M. et al. Dopamine agonists induce recovery from surgically-induced septal rage. Nature 269, 513–515 (1977). https://doi.org/10.1038/269513a0
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DOI: https://doi.org/10.1038/269513a0
