Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Review Article
  • Published:

Immunity to intestinal parasites

Nature volume 273, pages 617–620 (1978)Cite this article

Abstract

Intestinal parasites are common in man and animals and can cause severe disease. Knowledge of immunity to such infections is limited and comes largely from studies using laboratory host–parasite systems. Understanding how immunity can operate, and why it often does not, is not only of intrinsic interest but necessary for the development of immunological methods of control.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Poulain, J., Laffau, G. & Pery, P. Ann. Immun., Inst. Pasteur 127 C, 215–224 (1976).

    CAS  Google Scholar 

  2. Cypess, R. H., Ebersole, J. L. & Moliniari, J. A. Int. Archs Allergy appl. Immun. 55, 496–503 (1977).

    CAS  Google Scholar 

  3. Sinski, E. & Holmes, P. H. Expl Parasit. 43, 382–389 (1977).

    CAS  Google Scholar 

  4. Musoke, A. J., Williams, J. F., Leid, R. W. & Williams, C. S. F. Immunology 29, 845–853 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. Lloyd, S. & Soulsby, E. J. L. Immunology 34, 939–945 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Jones, V. E., Edwards, A. J. & Ogilvie, B. M. Immunology 18, 621–633 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Duncan, J. L., Smith, W. D. & Dargie, J. D. Vet. Parasit. 4, 21–27 (1978).

    CAS  Google Scholar 

  8. Despommier, D. D., McGregor, D. D., Crum, E. D. & Carter, P. B. Immunology 33, 797–805 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Di Conza, J. J. Expl Parasit. 25, 368–375 (1966).

    Google Scholar 

  10. Jones, V. E. & Ogilvie, B. M. Immunology 20, 546–561 (1971).

    Google Scholar 

  11. Wakelin, D. Parasitology 70, 397–405 (1975).

    PubMed  Google Scholar 

  12. Ogilvie, B. M. & Love, R. J. Transplantn Rev. 19, 147–168 (1974).

    CAS  Google Scholar 

  13. Ogilvie, B. M. & Hockley, D. J. J. Parasit. 54, 1073–1084 (1968).

    CAS  PubMed  Google Scholar 

  14. Lee, D. L. Parasitology 59, 29–39 (1969).

    CAS  PubMed  Google Scholar 

  15. Love, R. J., Ogilvie, B. M. & McLaren, D. J. Immunology 30, 7–15 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Love, R. J., Ogilvie, B. M. & McLaren, D. J. Parasitology 71, 275–283 (1975).

    CAS  PubMed  Google Scholar 

  17. Jacobson, R. H., Reed, N. D. & Manning, D. D. Immunology 32, 867–874 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  18. Ogilvie, B. M. Int. J. Parasit. 1, 161–167 (1971).

    CAS  Google Scholar 

  19. Sadun, E. H. in Immunity to Animal Parasites (ed. Soulsby, E. J. L.) 97–129 (Academic, New York, 1972).

    Google Scholar 

  20. Orr, T. S. C. & Blair, A. M. J. N. Life Sci. 8, 1073–1077 (1969).

    CAS  PubMed  Google Scholar 

  21. Jarrett, E. E. E. & Stewart, D. C. Immunology 23, 749–755 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Murray, M. in Immunity to Animal Parasites (ed. Soulsby, E. J. L.) 155–190 (Academic, New York, 1972).

    Google Scholar 

  23. Wakelin, D. Parasitology 57, 515–524 (1967).

    CAS  PubMed  Google Scholar 

  24. Behnke, J. M. Int. J. Parasit. 5, 511–515 (1975).

    CAS  Google Scholar 

  25. Jarrett, E. E. E., Urquhart, G. M. & Douthwaite, R. M. Expl Parasit. 24, 270–278 (1969).

    CAS  Google Scholar 

  26. Guy-Grand, D., Griselli, C. & Vassalli, P. Eur. J. Immun. 4, 435–443 (1974).

    CAS  Google Scholar 

  27. Rose, M. L., Parrott, D. M. V. & Bruce, R. G. Immunology 31, 723–730 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Love, R. J. & Ogilvie, B. M. Expl Parasit. 41, 124–132 (1977).

    CAS  Google Scholar 

  29. Wakelin, D. & Wilson, M. M. Parasitology 74, 215–224 (1977).

    CAS  PubMed  Google Scholar 

  30. Ogilvie, B. M., Love, R. J., Jarra, W. & Brown, K. N. Immunology 32, 521–528 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Mitchell, G. F., Hogarth-Scott, R. S., Edwards, R. D. & Moore, T. Int. Archs Allergy appl. Immun. 52, 95–104 (1976).

    CAS  Google Scholar 

  32. Jacobson, R. H. & Reed, N. D. Int. Archs Allergy appl. Immun. 52, 160–168 (1976).

    CAS  Google Scholar 

  33. Larsh, J. E. Adv. Parasit. 1, 213–286 (1963).

    Google Scholar 

  34. Rothwell, T. L. W. & Dineen, J. K. Immunology 22, 733–745 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Taliaferro, W. H. & Sarles, M. P. J. infect. Dis. 71, 69–82 (1939).

    Google Scholar 

  36. Castro, G. A., Roy, S. A. & Stockstill, R. D. Expl Parasit. 36, 307–315 (1974).

    CAS  Google Scholar 

  37. Castro, G. A., Badial-Aceves, F., Smith, J. W., Dudrick, S. J. & Weisbrodt, N. W. Gastroenterology 71, 620–625 (1976).

    CAS  PubMed  Google Scholar 

  38. Larsh, J. E. & Race, G. J. Expl Parasit. 37, 251–266 (1975).

    Google Scholar 

  39. Wakelin, D. & Wilson, M. M. Parasitology 74, 225–234 (1977).

    CAS  PubMed  Google Scholar 

  40. Dineen, J. K. & Kelly, J. D. Int. Archs Allergy appl. Immunol. 45, 759–766 (1973).

    CAS  Google Scholar 

  41. Ruitenberg, E. J., Elgersma, A., Kruizinga, W. & Leenstra, F. Immunology 33, 581–587 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  42. Andreassen, J., Hindso, O. & Ruitenberg, E. J. Immunology 34, 105–113 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Ruitenberg, E. J., Leenstra, F. & Elgersma, A. Br. J. exp. Path. 58, 311–314 (1977).

    CAS  Google Scholar 

  44. Jarrett, W. F. H., Jarrett, E. E. E., Miller, H. R. P. & Urquhart, G. M. in The Reaction of the Host to Parasitism (ed. Soulsby, E. J. L.) 191–198 (N. G. Elwert, Marburg, 1968).

    Google Scholar 

  45. Wells, P. D. Expl Parasit. 12, 82–101 (1962).

    CAS  Google Scholar 

  46. Kelly, J. D. & Ogilvie, B. M. Int. Archs Allergy appl. Immun. 43, 497–509 (1972).

    CAS  Google Scholar 

  47. Ogilvie, B. M., Mackenzie, C. D. & Love, R. J. Am. J. trop. Med Hyg. 26, 61–67 (1977).

    CAS  PubMed  Google Scholar 

  48. Murray, M., Jarrett, W. F. H. & Jennings, F. W. Immunology 21, 17–29 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  49. Stewart, D. F. Aust. J. agric. Res. 4, 100–117 (1953).

    Google Scholar 

  50. Urquhart, G. M., Mulligan, W., Eadie, R. M. & Jennings, F. W. Expl Parasit. 17, 210–217 (1965).

    CAS  Google Scholar 

  51. Mulligan, W., Urquhart, G. M., Jennings, F. W. & Neilson, J. T. M. Expl Parasit. 16, 341–347 (1965).

    CAS  Google Scholar 

  52. Barth, E. E. E., Jarrett, W. F. H. & Urquhart, G. M. Immunology 10, 459–464 (1966).

    PubMed Central  Google Scholar 

  53. McLaren, D. J., Mackenzie, C. D. & Ramalho-Pinto, F. J. Clin. exp. Immun. 30, 105–118 (1977).

    CAS  PubMed  Google Scholar 

  54. Larsh, J. E., Ottolenghi, A. & Weatherly, N. F. Expl Parasit. 36, 299–306 (1974).

    CAS  Google Scholar 

  55. Hubscher, T. J. Immun. 114, 1389–1393 (1975).

    CAS  PubMed  Google Scholar 

  56. Ottolenghi, A., Kocan, A. A., Weatherly, N. F. & Larsh, J. E. Expl Parasit. 38, 96–104 (1975).

    CAS  Google Scholar 

  57. Castro, G. A., Roy, S. A. & Schanbacher, L. M. J. Parasit. 61, 1053–1060 (1975).

    CAS  PubMed  Google Scholar 

  58. Grove, D. I., Mahmoud, A. A. F. & Warren, K. S. J. exp. Med. 145, 755–759 (1977).

    CAS  PubMed  Google Scholar 

  59. Rothwell, T. L. W., Prichard, R. K. & Love, R. J. Int. Archs Allergy appl. Immun. 46, 1–13 (1974).

    CAS  Google Scholar 

  60. Richards, A. J., Bryant, C., Kelly, J. D., Windon, R. G. & Dineen, J. K. Int. J. Parasit. 7, 153–158 (1977).

    CAS  Google Scholar 

  61. Rothwell, T. L. W., Love, R. J. & Goodrich, B. S. Int. Archs Allergy appl. Immun. 53, 93–95 (1977).

    CAS  Google Scholar 

  62. Dineen, J. K., Gregg, P., Windon, R. G., Donald, A. D. & Kelly, J. D. Int. J. Parasit. 7, 211–215 (1977).

    CAS  Google Scholar 

  63. Bruce, R. G. & Wakelin, D. Parasitology 74, 163–173 (1977).

    Google Scholar 

  64. Behnke, J. M., Bland, P. W. & Wakelin, D. Parasitology 75, 79–88 (1977).

    CAS  PubMed  Google Scholar 

  65. Roberts-Thomson, I. C., Grove, D. I., Stevens, D. P. & Warren, K. S. Gut 17, 953–958 (1976).

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Rowley, D. Aust. J. exp. Biol. med. Sci. 55, 1–18 (1977).

    CAS  PubMed  Google Scholar 

  67. Ogilvie, B. M. Parasitology 55, 325–335 (1965).

    CAS  PubMed  Google Scholar 

  68. Vernes, A. in Biochemistry of Parasites and Host-Parasite Relationships (ed.–Van den Bossche, H.) 319–324 (North-Holland, Amsterdam, 1976).

    Google Scholar 

  69. Poulain, J., Pery, P. & Luffau, G. Ann. Immun., Inst. Pasteur 127 C, 209–13 (1976).

    CAS  Google Scholar 

  70. Despommier, D. D., Campbell, W. C. & Blair, L. S. Parasitology 74, 109–119 (1977).

    CAS  PubMed  Google Scholar 

  71. Jenkins, S. N. & Wakelin, D. Parasitology 74, 153–161 (1977).

    Google Scholar 

  72. Keith, R. K. & Bremner, K. C. Res. vet. Sci. 15, 123–124 (1973).

    CAS  PubMed  Google Scholar 

  73. Mulligan, W., Gordon, H. McI., Stewart, D. F. & Wagland, B. M. Aust. J. agric. Res. 12, 1175–1187 (1961).

    Google Scholar 

  74. Miller, T. A. Adv. Parasit. 9, 153–183 (1971).

    CAS  Google Scholar 

  75. Love, R. J. & Ogilvie, B. M. Clin. exp. Immun. 21, 155–162 (1975).

    CAS  PubMed  Google Scholar 

  76. Dineen, J. K. & Kelly, J. D. Immunology 22, 1–12 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  77. Selby, G. R. & Wakelin, D. Parasitology 71, 77–85 (1975).

    CAS  PubMed  Google Scholar 

  78. Ogilvie, B. M. & Jones, V. E. Prog. Allergy 17, 93–144 (1973).

    CAS  PubMed  Google Scholar 

  79. Urquhart, G. M. et al. Amer. J. vet. Res. 27, 1641–1643 (1966).

    CAS  PubMed  Google Scholar 

  80. Bolin, T. D., Davis, A. E., Cummins, A. G., Duncombe, V. M. & Kelly, J. D. Gut 18, 182–186 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Urquhart, G. M., Murray, M., Murray, P. K., Jennings, F. W. & Bate, E. Trans. R. Soc. trop. Med. Hyg. 67, 528–535 (1973).

    CAS  PubMed  Google Scholar 

  82. Phillips, R. S., Selby, G. R. & Wakelin, D. Int. J. Parasit. 4, 409–415 (1974).

    CAS  Google Scholar 

  83. Phillips, R. S. & Wakelin, D. Expl Parasit. 39, 95–100 (1976).

    CAS  Google Scholar 

  84. Jenkins, D. C. Parasitology 71, 349–355 (1975).

    CAS  PubMed  Google Scholar 

  85. Jenkins, S. N. & Behnke, J. M. Parasitology 75, 71–78 (1977).

    CAS  PubMed  Google Scholar 

  86. Behnke, J. M., Wakelin, D. & Wilson, M. M. Expl Parasit. (in the press).

  87. Wakelin, D. Adv. Parasit. 16 (in the press).

  88. Long, P. L. in The Coccidia: Eimeria, Isopora, Toxoplasma and Related Genera (eds Hammond, D. M. & Long, P. L.) 254–294 (University Park Press, Baltimore, and Butterworth, London, 1973).

    Google Scholar 

  89. Long, P. L. & Rose, M. E. Parasitology 60, 147–155 (1970).

    CAS  PubMed  Google Scholar 

  90. Rose, M. E. in The Coccidia: Eimeria, Isopora, Toxoplasma and Related Genera (eds Hammond, D. M. & Long, P. L.) 295–341 (University Park Press, Baltimore, and Butterworth, London, 1973).

    Google Scholar 

  91. Mackaness, G. B. in Mononuclear Phagocytes (ed. van Furth, R.) 461–475 (Blackwell, Oxford, 1970).

    Google Scholar 

  92. Rose, M. E. Parasitology 62, 11–15 (1971).

    CAS  PubMed  Google Scholar 

  93. Orlans, E. & Rose, M. E. Immunochemistry 9, 833–838 (1972).

    CAS  PubMed  Google Scholar 

  94. Davis, P. J., Parry, S. H. & Porter, P. Immunology 34, 879–888 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  95. Rose, M. E. & Hesketh, P. Parasitology 73, 25–37 (1976).

    CAS  PubMed  Google Scholar 

  96. Rose, M. E. & Long, P. L. Parasitology 63, 299–313 (1971).

    CAS  PubMed  Google Scholar 

  97. Liburd, E. M., Armstrong, W. D. & Mahrt, J. L. Cell. Immun. 7, 444–452 (1973).

    CAS  Google Scholar 

  98. Ogilvie, B. M. & Rose, M. E. INSERM, Paris 72, 237–248 (1977).

  99. Rose, M. E. & Long, P. L. in Biochemistry of Parasites and Host-Parasite Relationships (ed. Van den Bossche, H.) 449–455 (North Holland, Amsterdam 1976).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Wellcome Laboratories for Experimental Parasitology, Department of Zoology, University of Glasgow, UK

    D. Wakelin

Authors
  1. D. Wakelin
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wakelin, D. Immunity to intestinal parasites. Nature 273, 617–620 (1978). https://doi.org/10.1038/273617a0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/273617a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing