Abstract
THE genome of the avian influenza virus A/fowl plague/27 (A/FPV) and other influenza A virsuses consists of eight species of single-stranded RNA1–3. Each of these RNAs represents the gene for one virus-coded polypeptide, and RNA–polypeptide assignments have been made for several influenza A virus strains3,4. Furthermore, in suitable conditions the RNA fragments of different influenza A viruses migrate at different rates in polyacrylamide slab gels containing 6M urea and differences in the polypeptide migration rates can be measured3–5. Thus, in recombinant influenza viruses, which are commonly used as candidate attenuated vaccine strains (see ref. 6 for review), the parental origin of each RNA gene can now be established. We report here the first analysis of the genomes of a set of human influenza virus recombinants of defined virulence. By analysis of the parental origins of the recombinants' genomes we attempted to answer questions concerning the relationship of possible gene groups or constellations to virus virulence and attenuation.
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OXFORD, J., MCGEOCH, D., SCHILD, G. et al. Analysis of virion RNA segments and polypeptides of influenza A virus recombinants of defined virulence. Nature 273, 778–779 (1978). https://doi.org/10.1038/273778a0
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DOI: https://doi.org/10.1038/273778a0
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