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Muscular fatigue investigated by phosphorus nuclear magnetic resonance

Nature volume 274, pages 861–866 (1978)Cite this article

Abstract

Muscular fatigue has been studied using 31P NMR to measure the levels and rates of utilisation of several key metabolites and the free-energy change for ATP hydrolysis. Force development is closely correlated with metabolite levels and is proportional to the rate at which ATP is hydrolysed.

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References

  1. Dawson, M. J., Gadian, D. G. & Wilkie, D. R. J. Physiol., Lond. 267, 703–735 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Dawson, M. J., Gadian, D. G. & Wilkie, D. R. NMR in Biology (eds Dwek, R. A., Campbell, I. D., Richards, R. E. & Williams, R. J. P.) 289–322 (Academic, London, 1977).

    Google Scholar 

  3. Lehman, C. F. Lehrbuch der physiologischen Chemie, 1850; and page 98 in 2nd edn translated by Day, G. E. (Cavendish Society, London, 1851).

    Google Scholar 

  4. Bárány, M., Bárány, K., Burt, C. T., Glonek, T. & Myers, T. C. J. supramolec. Struct. 3, 125–140 (1975).

    Article  Google Scholar 

  5. Gilbert, C., Kretzschmar, K. M., Wilkie, D. R. & Woledge, R. C. J. Physiol., Lond. 218, 163–193 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Distèche, A. Mem. Acad. r. Belg. Cl. Sci. 8°serie 2, 32, 1–169 (1960).

    Google Scholar 

  7. Stella, G. J. Physiol., Lond. 66, 19–31 (1928).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wilkie, D. R. A. Rev. Physiol. 28, 17–38 (1966).

    Article  CAS  Google Scholar 

  9. Noda, L., Kuby, S. A. & Lardy, H. A. J. biol. Chem. 210, 83–95 (1954).

    CAS  PubMed  Google Scholar 

  10. Cohen, S. M. & Burt, C. T. Proc. natn. Acad. Sci. U.S.A. 74, 4271–4275 (1977).

    Article  ADS  CAS  Google Scholar 

  11. Alberty, R. A. J. biol. Chem. 244, 3290–3302 (1969).

    CAS  PubMed  Google Scholar 

  12. Belaich, J. P. & Sari, J. C. Proc. natn. Acad. Sci. U.S.A. 64, 763–770 (1969).

    Article  ADS  CAS  Google Scholar 

  13. Gadian, D. G. thesis, Oxford Univ. (1974).

  14. Hoult, D. I. et al. Nature 252, 285–287 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Burt, C. T., Glonek, T. & Bárány, M. J. biol. Chem. 251, 2584–2591 (1976).

    CAS  PubMed  Google Scholar 

  16. Vergara, J. L., Rapoport, S. I. & Nassar-Gentina, V. Am. J. Physiol. 232, C185–C190.(1977).

    Article  CAS  PubMed  Google Scholar 

  17. Grabowski, W., Lobsiger, E. A. & Lüttgau, H.Ch. Pflügers Arch. 334, 222–239 (1972).

    Article  CAS  PubMed  Google Scholar 

  18. Spande, J. I. & Schottelius, B. A. Am. J. Physiol 219, 1490–1495, (1970).

    CAS  PubMed  Google Scholar 

  19. Trentham, D. R., Eccleston, J. F. & Bagshaw, C. R. Q. Rev. Biophys. 9, 217–281 (1976).

    Article  CAS  PubMed  Google Scholar 

  20. Fabiato, A. & Fabiato, F. J. Physiol., Lond. 276, 233–255 (1978).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Quantities, Units and Symbols, (The Royal Society, London, 1975).

  22. Mainwood, G. W., Worsley-Brown, P. & Paterson, R. A. Can. J. Physiol. Pharmac. 50, 143–155 (1972).

    Article  CAS  Google Scholar 

  23. Curtin, N. A. & Woledge, R. C. Physiol. Rev. (in the press).

  24. Stella, G. J. Physiol., Lond. 68, 49–66 (1929/1930).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. De Furia, R. R. & Kushmerick, M. J. Am. J. Physiol. 232, C30–C36 (1977).

    Article  CAS  Google Scholar 

  26. Hartree, W. & Hill, A. V. J. Physiol., Lond. 55, 133–158 (1921).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Aubert, X. Le Couplage Energetique de la Contraction Musculaire (Arscia, Brussels, 1956).

    Google Scholar 

  28. Maréchal, G. & Mommaerts, W. F. H. M. Biochim. biophys. Acta 70, 53–67 (1963).

    Article  PubMed  Google Scholar 

  29. Homsher, E., Rall, J. A., Wallner, A. & Ricchiuti, N. V. J. gen. Physiol. 65, 1–21 (1975).

    Article  CAS  PubMed  Google Scholar 

  30. Curtin, N. A., Gilbert, C., Kretzschmar, K. M. & Wilkie, D. R. J. Physiol., Lond. 238, 455–472 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Homsher, E., Mommaerts, W. F. H. M., Ricchiuti, N. V. & Wallner, A. J. Physiol., Lond. 220, 601–625 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Smith, I. C. H. J. Physiol., Lond. 220, 583–599 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Burt, C. T., Glonek, T. & Bárány, M. Biochemistry 15, 4850–4853 (1977).

    Article  Google Scholar 

  34. Chalovich, J. M., Burt, C. T., Cohen, S. M., Glonek, T. & Bárány, M. Archs Biochem. Biophys. 182, 683–689 (1977).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, University College London, Gower Street, London, WC1

    M. Joan Dawson, D. G. Gadian & D. R. Wilkie

  2. Department of Biochemistry, University of Oxford, Oxford, UK

    M. Joan Dawson

Authors
  1. M. Joan Dawson
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  2. D. G. Gadian
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  3. D. R. Wilkie
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Joan Dawson, M., Gadian, D. & Wilkie, D. Muscular fatigue investigated by phosphorus nuclear magnetic resonance. Nature 274, 861–866 (1978). https://doi.org/10.1038/274861a0

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