Abstract
THE Abelson murine leukaemia virus (A-MuLV) complex, which consists of a replication-defective focus-forming virus and its helper Moloney leukaemia virus, causes a thymus-independent lymphosarcoma in BALB/c mice1. Infection in vivo leads to the production of tumours which are usually classified as ‘null’ lymphoid cells2, although immunoglobulin (Ig)-synthesising B-cell lines have been reported3–5 and macrophage lines may occasionally be produced6. In some cases, particularly with pretreatment of the mice with the mineral oil pristane, there is a high incidence of Ig-producing plasmacytomas7. Additional data on Ly phenotypes have suggested that most A-MuLV tumours, including those with no demonstrable Ig synthesis, may be B-cell lineage derivatives8. Here, we provide evidence for A-MuLV transformation of B-cell precursors resulting in two cell lines which retain the capacity for inducible IgM synthesis. Line ABC-1 was derived from BALB/c mouse bone marrow cells transformed in vitro by the Abelson virus9 and line ATV-3 from a tumour in a BALB/c mouse inoculated with A-MuLV.
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Boss, M., GREAVES, M. & TEICH, N. Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristics. Nature 278, 551–553 (1979). https://doi.org/10.1038/278551a0
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DOI: https://doi.org/10.1038/278551a0
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