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Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

Nature volume 283, pages 162–167 (1980)Cite this article

Abstract

The receptor-mediated endocytosis of α2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

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Authors and Affiliations

  1. Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20205

    Peter J. A. Davies, Dana R. Davies, Alexander Levitzki, Frederick R. Maxfield, Pierre Milhaud, Mark C. Willingham & Ira H. Pastan

  2. The Hebrew University, Jerusalem, Israel

    Alexander Levitzki

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  1. Peter J. A. Davies
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  2. Dana R. Davies
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  3. Alexander Levitzki
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  4. Frederick R. Maxfield
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  5. Pierre Milhaud
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  6. Mark C. Willingham
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  7. Ira H. Pastan
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Davies, P., Davies, D., Levitzki, A. et al. Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones. Nature 283, 162–167 (1980). https://doi.org/10.1038/283162a0

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