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Lethal metabolism of precocene-I to a reactive epoxide by locust corpora allata

Abstract

The corpora allata from adult female Locusta migratoria rapidly metabolise precocene-I to a geometric mixture of dihydrodiols, and simultaneously suffer extensive macromolecular labelling. This could explain the selective cell death which precocenes induce, and focuses attention on the high level of epoxidase in these insect organs.

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Pratt, G., Jennings, R., Hamnett, A. et al. Lethal metabolism of precocene-I to a reactive epoxide by locust corpora allata. Nature 284, 320–323 (1980). https://doi.org/10.1038/284320a0

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