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Dopaminergic stimulation of prolactin release

Nature volume 285, pages 243–246 (1980)Cite this article

Abstract

Prolactin (PRL) secretion from anterior pituitary is believed to be under tonic inhibitory control of dopamine (DA)1 released from the tubero-infundibular dopaminergic neurones into the hypophysial portal blood2–4. Inhibition of PRL release by DA seems to be mediated by stereospecific DA receptors located in PRL cells5,6. Apomorphine and various ergot alkaloids such as bromocryptine mimic the inhibitory effect of DA both in vivo and in vitro, presumably by a direct agonist action on these ‘inhibitory’ receptors1,6,7. We now report that PRL secretion in primary cultures of rat pituitary cells can be stimulated by DA when concentrations a thousand times lower than those required for inhibition are used. Secretion rates above basal release can also be induced by apomorphine and bromocryptine when the ‘inhibitory’ receptors are blocked with certain DA receptor antagonists.

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Authors and Affiliations

  1. Laboratory of Cell Pharmacology, Department of Pharmacology, Leuven, School of Medicine, Campus Gasthuisberg, K.U. B-3000, Leuven, Belgium

    Carl Denef, Danielle Manet & Raymonde Dewals

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  1. Carl Denef
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  2. Danielle Manet
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  3. Raymonde Dewals
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Denef, C., Manet, D. & Dewals, R. Dopaminergic stimulation of prolactin release. Nature 285, 243–246 (1980). https://doi.org/10.1038/285243a0

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