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Decreased rate of DNA-chain growth in human basal cell carcinoma

Nature volume 285, pages 265–267 (1980)Cite this article

Abstract

The DNA synthetic (S) phase of cell division is about twice as long in human basal cell carcinoma (BCC) as in the normal epidermis and several non-malignant skin diseases1–3. A similar increase in S phase duration seems to occur in tumours of the human oesophagus4, larynx4 and recto-colon5,6. At the molecular level, the overall rate of replication in a nucleus is determined by two factors—the frequency of initiation of replication and the rate of replication fork progression along the units of replication (for review see refs 7,8). Here we present evidence (based on DNA fibre autoradiography9–11) that the observed increase in S phase duration may be due to a marked reduction in the rate of DNA replication along replication units, the density of simultaneously operating replication units remaining unchanged. This indicates an alteration in some biological component(s) of DNA synthesis in BCC that is of potential interest for characterizing the malignant transformation of the epidermal cell and that may perhaps be exploited therapeutically.

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Authors and Affiliations

  1. Biology Unit, Institute of Interdisciplinary Research and Department of Dermatology, School of Medicine, Free University of Brussels, 2 rue Evers, 1000, Brussels, Belgium

    M. Heenen & P. Galand

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  1. M. Heenen
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  2. P. Galand
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Heenen, M., Galand, P. Decreased rate of DNA-chain growth in human basal cell carcinoma. Nature 285, 265–267 (1980). https://doi.org/10.1038/285265a0

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