Abstract
Seven monoclonal antibodies have been produced against a membrane preparation from adult rat retina. Three antibodies reacted with particular regions of rat photoreceptor cell surfaces: RET-P1 labelled the cell bodies, outer and inner segments (rods but not cones), RET-P2 labelled only outer segments and RET-P3 labelled only the cell bodies. Three antibodies reacted with glial cells; RET-G2 and RET-G3 were specific for Müller cells, RET-G1 also labelled glia elsewhere in brain. The seventh antibody (RET-N1) reacted with many types of neuronal cells.
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Sidman, R. L. 3rd Lepetit Colloquium on Cell Interactions (ed. Silvestri, L. G.), 1–13 (North-Holland, Amsterdam, 1972).
Moscona, A. A. (ed.) The Cell Surface in Development (Wiley, New York, 1974).
Rutishauser, V., Brackenbury, R., Thiery, J. P. & Edelman, G. M. Birth Defects: Original Article Series XIV, 305–316 (1978).
Krnjevic, K. Physiol. Rev. 54, 418–540 (1974).
Hall, Z., Kelly, R. & Fox, C. F. (eds) Cellular Neurobiology (Liss, New York, 1977).
Fields, K. L., Gosling, C., Megson, M. & Stern, P. L. Proc. natn. Acad. Sci. U.S.A. 72, 1296–1300 (1975).
Schachner, M., Ruberg, M. Z. & Carnow, T. B. Brain Res. Bull. 1, 367–377 (1976).
Stallcup, W. B. & Cohn, M. Expl Cell Res. 98, 285–297 (1976).
Raff, M. C. et al. Brain Res. 174, 283–308 (1979).
Köhler, G. & Milstein, C. Nature 256, 495–497 (1975).
Galfre, G., Howe, S. C., Milstein, C., Butcher, G. W. & Howard, J. C. Nature 266, 550–552 (1977).
Standring, R., McMaster, W. R., Sunderland, C. A. & Williams, A. F. Eur. J. Immun. 8, 832–839 (1978).
White, R. A. H. et al. J. exp. Med. 14, 664–673 (1978).
Reinherz, E. L., Kung, P. C., Goldstein, G. & Schlossman, S. F. Proc. natn. Acad. Sci. U.S.A. 76, 4061–4065 (1979).
Barnstable, C. J. et al. Cell 14, 9–20 (1978).
Werblin, F. S. & Dowling, J. E. J. Neurophysiol. 32, 339–355 (1969).
Hubel, D. H. & Wiesel, T. N. J. Physiol., Lond. 155, 385–398 (1961).
Hubel, D. H. & Wiesel, T. N. Proc. R. Soc. B 198, 1–59 (1977).
Dowling, J. E. & Boycott, B. B. Proc. R. Soc. B 166, 80–111 (1966).
Bader, C. R., MacLeish, P. R. & Schwartz, E. A. J. Physiol., Lond. 296, 1–26 (1979).
Lam, D. M. K. Cold Spring Harb. Symp. quant. Biol. 40, 571–579 (1975).
Sarthy, V. P. & Lam, D. M. K. J. Neurochem. 32, 455–461 (1979).
Barclay, A. N., Letarte-Muirhead, M. & Williams, A. F. Biochem. J. 151, 699–706 (1975).
Brodsky, F. M., Parham, P., Barnstable, C. J., Crumpton, M. J. & Bodmer, W. F. Immun. Rev. 47, 3–61 (1979).
Williams, A. F. Contemporary Topics molec. Immun. 6, 93–116 (1977).
Barclay, A. N. Brain Res. 133, 139–143 (1977).
Cajal, S. R. The Structure of the Retina (Translators Thorpe, S. A. & Glickstein, M.) (Thomas, Illinois, 1972).
Young, R. W. J. Ultrastruct. Res. 23, 462–473 (1968).
Papermaster, D. S., Converse, C. A. & Zorn, M. A. Expl Eye Res. 23, 105–116 (1978).
La Vail, M. M. Invest. Ophthal. 15, 64–70 (1976).
Cohen, A. I. Vision Res. 10, 445–453 (1970).
Dewey, M. M., David, P. K., Blasie, J. K. & Barr, L. J. molec. Biol. 39, 395–405 (1969).
Uga, S. & Smelser, G. K. Invest. Ophthal. 12, 295–307 (1973).
Miller, R. E. & Dowling, J. E. J. Neurophysiol. 33, 323–341 (1970).
Cajal, S. R. Histologie du Systeme Nerveux de l'Homme et des Vertebres Vol. II (CSIC, Madrid, 1955).
Neal, M. J. & Iversen, L. L. Nature new Biol. 235, 217–218 (1972).
Voaden, M. J. in Transmitters in the Visual Process (ed. Bonting, S. L.) 107–125 (Pergamon, Oxford, 1976).
Sarthy, P. V. & Lam, D. M. K. Brain Res. 176, 208–212 (1980).
Peters, A., Palay, S. L. & Webster, H. de F. The Fine Structure of the Nervous System (Saunder, Philadelphia, 1976).
Kuffler, S. W., Nicholls, J. G. & Orkand, R. K. J. Neurophysiol. 36, 855–868 (1966).
Iverson, L. L. & Kelly, J. S. Biochem. Pharmac. 24, 933–938 (1975).
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Barnstable, C. Monoclonal antibodies which recognize different cell types in the rat retina. Nature 286, 231–235 (1980). https://doi.org/10.1038/286231a0
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DOI: https://doi.org/10.1038/286231a0
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