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Surface activation of blood coagulation, fibrinolysis and kinin formation

Nature volume 286, pages 456–460 (1980)Cite this article

Abstract

The activation of plasma prekallikrein by single-chain factor XII has been studied in the presence of high molecular weight kininogen and kaolin. The data indicate that factor XII can initiate blood coagulation, fibrinolysis or kinin generation in the presence of kaolin and does so by converting prekallikrein to kallikrein. An enzyme cascade is then generated leading to the formation of fibrin, plasmin or bradykinin in three closely related physiological events.

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Authors and Affiliations

  1. Department of Biochemistry, University of Washington, Seattle, Washington, 98195

    Ronald L. Heimark, Kotoku Kurachi, Kazuo Fujikawa & Earl W. Davie

Authors
  1. Ronald L. Heimark
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  2. Kotoku Kurachi
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  3. Kazuo Fujikawa
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  4. Earl W. Davie
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Heimark, R., Kurachi, K., Fujikawa, K. et al. Surface activation of blood coagulation, fibrinolysis and kinin formation. Nature 286, 456–460 (1980). https://doi.org/10.1038/286456a0

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