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Enkephalin blocks inhibitory pathways in the vertebrate CNS

Nature volume 287, pages 22–25 (1980)Cite this article

Abstract

Enkephalin markedly attenuates a variety of GABAergic inhibitory pathways in the CNS, but does not affect the action of GABA. The action of enkephalin is reversed by the specific opiate antagonist, naloxone. Thus, inhibitory interneurones may be primary targets for opioid peptide-containing pathways and disinhibition may be of general importance for opioid peptide action in the CNS.

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Authors and Affiliations

  1. Departments of Pharmacology and Physiology, University of California, San Francisco, California, 94143

    R. A. Nicoll, B. E. Alger & C. E. Jahr

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  1. R. A. Nicoll
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  2. B. E. Alger
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  3. C. E. Jahr
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Nicoll, R., Alger, B. & Jahr, C. Enkephalin blocks inhibitory pathways in the vertebrate CNS. Nature 287, 22–25 (1980). https://doi.org/10.1038/287022a0

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