Abstract
The direct oncogenic potential of X rays has been demonstrated by the in vitro neoplastic transformation of mammalian cells in culture1, a technique which permits the study of oncogenesis in the absence of host-specific effects. Although several agents are known to modulate in vitro neoplastic transformation by X rays2, little is known of the effects of hormones. We now describe experiments which show that the presence of thyroid hormone is necessary for in vitro neoplastic transformation by X rays in cells of an established mouse fibroblast culture (C3H/10T1/2) and in early-passage diploid hamster embryo cells.
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Guernsey, D., Ong, A. & Borek, C. Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation. Nature 288, 591–592 (1980). https://doi.org/10.1038/288591a0
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DOI: https://doi.org/10.1038/288591a0
