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Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation

Nature volume 289, pages 373–378 (1981)Cite this article

Abstract

Four ‘antigenic sites’ on the three-dimensional structure of the influenza haemagglutinin are identified. At least one amino acid substitution in each site seems to be required for the production of new epidemic strains between 1968 and 1975.

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Authors and Affiliations

  1. Gibbs Laboratory, Harvard University, 12 Oxford Street, Cambridge, Massachusetts, 02138

    D. C. Wiley & I. A. Wilson

  2. National Institute for Medical Research, Mill Hill, London, NW7 1AA, UK

    J. J. Skehel

Authors
  1. D. C. Wiley
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  2. I. A. Wilson
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  3. J. J. Skehel
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Wiley, D., Wilson, I. & Skehel, J. Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289, 373–378 (1981). https://doi.org/10.1038/289373a0

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