Photoperiodicity in the male albino laboratory rat

Abstract

Animals inhabiting areas where there are drastic changes in the environment often reproduce only during limited time periods to ensure that young are raised in optimal environmental conditions¹. The lack of a well defined breeding season in many domesticated animals^2,3, presumably because the selective pressures for seasonal breeding have been minimized, suggests that the neuroendocrine events controlling seasonal cyclicity have been bred out of these animals. Little is known about the underlying neuroendocrine changes which may occur during the evolution of a species from a seasonal to a nonseasonal breeder. Whereas the changing photoperiod is the primary environmental cue which initiates and/or terminates the reproductive season in many animals⁴, this is not so in the albino rat Rattus norvegicus, a model nonseasonal breeder^5–7. Nevertheless, daylength can influence various reproductive parameters in laboratory rats ^8–17, suggesting that some of the neuroendocrine components that controlled seasonal breeding previously are still extant in this species. To test this hypothesis, we investigated the effect of daylength on the responsiveness of the neuroendocrine–gonadal axis to the negative-feedback effects of testosterone. This paradigm was chosen because of the important role played by photic-induced changes in steroid feedback sensitivity in the control of seasonal reproduction^18–21. We report here that although daylength has very little effect on neuroendocrine–gonadal function in the intact male laboratory rat, it seems that some component(s) of a photoperiodic system involving the pineal gland has been preserved.