Abstract
Normal human urine inhibits monoamine oxidase (MAO)1. This inhibitory activity, which is also present in rat urine, cannot be accounted for by a large range of known urinary constituents, including certain monoamines or their metabolites, but is caused by an unidentified low-molecular-weight compound(s). Endogenous MAO inhibitors may be important as physiological regulators; there have been reports of a decrease in platelet MAO activity, conceivably deriving from their presence, in a variety of human disease states2. We show here that cold immobilization stress markedly increases the output of rat urine MAO inhibitor, and that this increase is attenuated by benzodiazepine drugs.
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References
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Glover, V., Bhattacharya, S., Sandler, M. et al. Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor. Nature 292, 347–349 (1981). https://doi.org/10.1038/292347a0
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DOI: https://doi.org/10.1038/292347a0
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