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Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation

Nature volume 292, pages 355–357 (1981)Cite this article

Abstract

Graft-versus-host disease (GvHD) is a cell-mediated imiminological reaction, and there is evidence in the rodent system that long-term survival without GvHD is associated with the presence of lymphocytes which specifically suppress the GvH reaction. We have accordingly developed an assay for the influence of circulating cells from patients with HLA-identical marrow grafts on the reaction of donor cells against host lymphocytes (collected before transplantation and modified by trinitrophenyl (TNP)). We find that patients without GvHD have radiation-sensitive circulating cells which specifically suppress the in vitro model of the GvH reaction. Our findings seem to have a bearing on graft–host tolerance and the causation of GvHD in vivo.

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center and Department of Medicine, Division of Oncology, University of Washington School of Medicine, Seattle, Washington, 98104, USA

    Mang-So Tsoi, Rainer Storb, Sherrie Dobbs & E. Donnall Thomas

Authors
  1. Mang-So Tsoi
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  2. Rainer Storb
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  3. Sherrie Dobbs
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  4. E. Donnall Thomas
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Tsoi, MS., Storb, R., Dobbs, S. et al. Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation. Nature 292, 355–357 (1981). https://doi.org/10.1038/292355a0

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