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Acumentin, a protein in macrophages which caps the ‘pointed’ end of actin filaments

Nature volume 297, pages 303–307 (1982)Cite this article

Abstract

Macrophages have a calcium-insensitive protein which binds to and inhibits monomer addition at the ‘pointed’ end of actin filaments labelled with heavy meromyosin. This protein, in concert with calcium-sensitive proteins already shown to bind the ‘barbed’ end of filaments, can lead to complete control of actin filament length in the cytoplasm. The blocking of actin filament ends in low as well as high calcium concentrations would prevent treadmilling in living cells.

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Authors and Affiliations

  1. Hematology–Oncology and Infectious Disease Units, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02114, USA

    Frederick S. Southwick & John H. Hartwig

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  1. Frederick S. Southwick
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  2. John H. Hartwig
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Southwick, F., Hartwig, J. Acumentin, a protein in macrophages which caps the ‘pointed’ end of actin filaments. Nature 297, 303–307 (1982). https://doi.org/10.1038/297303a0

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