Abstract
Recent work has shown that established B-cell tumours, previously thought to proliferate independently of immune regulation, may activate, and be regulated by, helper or suppressor T-cell subpopulations1–7. We now report a unique model of a murine sarcoma virus (MSV) induced B-cell lymphoma which is closely associated with a population of pre-malignant or malignant helper T cells. Proliferation of these T cells is not observed in vivo but is readily detected on in vitro cultivation. These results raise questions about immunological control and differentiation of malignant lymphomas in vivo.
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References
Chiorazzi, N. et al. J. Immun. 122, 1087–1090 (1979).
Rohrer, J. W. & Lynch, R. G. J. Immun. 121, 1066–1074 (1978).
Rohrer, J. W., Odermatt, B. & Lynch, R. G. J. Immun. 122, 2011–2019 (1979).
Lynch, R. G., Rohrer, J. W., Gebel, H. M. & Odermatt, B. in Progress in Myeloma (ed. Potter, M.) 129–150 (Elsevier, Amsterdam, 1980).
Abbas, A. K. J. Immun. 123, 2011–2018 (1979).
Abbas, A. K., Perry, L. I., Bach, B. A. & Greene, M. I. J. Immun. 124, 1160–1166 (1980).
Abbas, A. K., Burakoff, S. J., Gefter, M. L. & Greene, M. I. J. exp. Med. 152, 969–978 (1980).
Lukes, R. J. & Collins, R. D. Br. J. Cancer 31, suppl 2, 1–28 (1975).
Reinisch, C. L., Gleiner, N. A. & Schlossman, S. F. J. Immun. 116, 710–715 (1976).
Reinisch, C. L., Kurtz, S. L., Morris, E. A. & Lampert, A. Am. J. Path. 101, 265–282 (1980).
Ledbetter, J. A., Goding, J. W., Tokuhisa, T. & Herzenberg, L. A. in Monoclonal Antibodies (eds Kennett, R. H., McKearn, T. J. & Bechtol, K.) 235–249 (Plenum, New York, 1980).
Andrew, S. L., Strelkauskas, A. J., Kurtz, S. L., O'Connell, K. & Reinisch, C. L. Cell. Immun. 48, 407–416 (1979).
Rosenson, R. S., Flaherty, L. & Reinisch, C. L. J. Immun. 126, 2253–2257 (1981).
Chang, T. W. & Eisen, H. Nature 280, 406–408 (1979).
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Reinisch, C., Sing, A., Waldron, J. et al. Isolation of malignant and functional Ly 1+ T-cell clones from B-cell lymphomas. Nature 298, 176–178 (1982). https://doi.org/10.1038/298176a0
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DOI: https://doi.org/10.1038/298176a0
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