Abstract
Delayed-type hypersensitivity (DTH) to both major histocompatibility complex (H–2) and non-H–2-coded antigens can be induced by subcutaneous immunization with allogeneic lymphoid cells in the mouse. While subcutaneous immunization with allogeneic cells preferentially induces DTH reactivity, intravenous immunization, especially with irradiated allogeneic cells, induces a state of suppression. Suppression is manifest both in direct host-versus-graft (HvG)1 assays and under graft-versus-host (GvH) conditions2, where spleen cells of suppressed mice are used to reconstitute irradiated allogeneic hosts. The suppression is mediated by T cells2,3. We have now studied the specificity of the suppressive effect by subcutaneous immunization of ‘suppressed’ mice with a combination of alloantigens comprising the antigen(s) used to induce the suppressor T cells as well as unrelated alloantigens. We report here that reaction against the third party alloantigens was effectively suppressed, provided these antigens were presented in combination with the antigen(s) that had induced the suppressor T cells. Both sets of alloantigens do not need to be physically associated.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Van der Kwast, Th. H., Bianchi, A. T. J., Bril, H. & Benner, R. Transplantation 31, 79–85 (1981).
Bril, H. & Benner, R. Adv. exp. Med. Biol. 149, 577–583 (1982).
Bianchi, A. T. J., Hussaarts-Odijk, L. M. & Benner, R. Transplantn Proc. (in the press).
Wolters, E. A. J. & Benner, R. Nature 279, 642–643 (1979).
Wolters, E. A. J. & Benner, R. Transplantation 26, 40–45 (1978).
Wolters, E. A. J. & Benner, R. Transplantation 27, 39–42 (1979).
Liew, F. Y. Eur. J. Immun. 11, 883–888 (1981).
Zembala, M., Asherson, G. L. & Colizzi, W. Nature 297, 411–413 (1982).
Rich, S. S. & Rich, R. R. J. exp. Med. 140, 1588–1602 (1974).
Rich, S. S. & Rich, R. R. J. exp. Med. 142, 1391–1402 (1975).
Fresno, M., Nabel, G., McVay-Boudreau, L., Furthmayer, H. & Cantor, H. J. exp. Med. 153, 1246–1259 (1981).
Fresno, M., McVay-Boudreau, L., Nabel, G. & Cantor, H. J. exp. Med. 153, 1260–1274 (1981).
Fresno, M., McVay-Boudreau, L. & Cantor, H. J. exp. Med. 155, 981–993 (1982).
Asherson, G. L. & Zembala, M. Immunology 42, 1005–1013 (1980).
Claman, H. N., Miller, S. D., Conlon, P. J. & Moorhead, J. W. Adv. Immun. 30, 121–157 (1980).
Miller, S. D., Sy, M.-S. & Claman, H. N. J. Immun. 121, 265–273 (1978).
Bach, B. A., Sherman, L., Benacerraf, B. & Greene, M. I. J. Immun. 121, 1460–1468 (1978).
Miller, S. D., Sy, M.-S. & Claman, H. N. J. Immun. 121, 274–280 (1978).
Dietz, M. H. et al. J. exp. Med. 153, 450–463 (1981).
Sy, M.-S., Nisonoff, A., Germain, R. N., Benacerraf, B. & Greene, M. I. J. exp. Med. 153, 1415–1425 (1981).
Bianchi, A. T. J., Van der Kwast, Th. H. & Benner, R. Immun. Today 3, 123–124 (1982).
Opelz, G., Sengar, D. P. S., Mickey, W. R. & Terasaki, P. I. Transplantn Proc. 5, 253–259 (1973).
Williams, K. A. & Morris, P. J. in Organ Transplantation—Present State, Future Goals (ed. Slavin, S.) (Elsevier, Amsterdam 1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bianchi, A., Bril, H. & Benner, R. Alloantigen-specific suppressor T cells can also suppress the in vivo immune response to unrelated alloantigens. Nature 301, 614–616 (1983). https://doi.org/10.1038/301614a0
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/301614a0
