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Cyclic AMP stabilizes a class of developmentally regulated Dictyostelium discoideum mRNAs

Nature volume 301, pages 616–618 (1983)Cite this article

Abstract

The stability of mRNA is an important facet of the regulation of protein synthesis. In mammalian cells most mRNAs have long half-lives (5–15 hours) but a substantial fraction are much less stable1,2. There are few examples where the stability of a particular mRNA or class of mRNAs is specifically affected by environmental or developmental stimuli. Certain hormones cause specific stabilization of mRNAs species3 and preferential mRNA stability is important in the accumulation of globin and myosin mRNAs during the terminal stages of erythropoesis or myogenesis, respectively4–7. Disaggregation of Dictyostelium discoideum aggregates induces the specific destabilization of a large class of developmentally regulated mRNAs; thus, this system is an excellent one in which to determine how such controls are effected8–10. Here we show that addition of cyclic AMP to disaggregated cells specifically prevents the destabilization of these mRNAs.

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Authors and Affiliations

  1. Cattedra di Biologia Generale, Istituto di Igiene, University of Turin, Italy

    Giorgio Mangiarotti & Adriano Ceccarelli

  2. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Giorgio Mangiarotti & Harvey F. Lodish

Authors
  1. Giorgio Mangiarotti
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  2. Adriano Ceccarelli
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  3. Harvey F. Lodish
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Mangiarotti, G., Ceccarelli, A. & Lodish, H. Cyclic AMP stabilizes a class of developmentally regulated Dictyostelium discoideum mRNAs. Nature 301, 616–618 (1983). https://doi.org/10.1038/301616a0

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