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Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene

Nature volume 304, pages 135–139 (1983)Cite this article

Abstract

Recombinant DNA clones have been used to directly demonstrate that the Burkitt lymphoma cell line Raji, t(8;14) (q24;q32), has a rearranged copy of the c-myc gene adjacent to the γ1 constant region gene of the human immunoglobulin heavy-chain locus ; the genes are arranged in the opposite direction for transcription. At least one further 5′ exon has been detected in the normal c-myc gene by analysis of RNA transcripts, and the occurrence of high levels of two c-myc mRNA size classes, both apparently initiating in this exon, is described.

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Authors and Affiliations

  1. Ludwig Institute for Cancer Research, MRC Centre, Hills Road, Cambridge, CB2 2QH, UK

    P. H. Hamlyn

  2. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    T. H. Rabbitts

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  1. P. H. Hamlyn
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  2. T. H. Rabbitts
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Hamlyn, P., Rabbitts, T. Translocation joins c-myc and immunoglobulin γ1 genes in a Burkitt lymphoma revealing a third exon in the c-myc oncogene. Nature 304, 135–139 (1983). https://doi.org/10.1038/304135a0

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