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Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
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  • Article
  • Published: 09 February 1984

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

  • J. Downward1,
  • Y. Yarden2,
  • E. Mayes1,
  • G. Scrace1,
  • N. Totty1,
  • P. Stockwell1 nAff4,
  • A. Ullrich3,
  • J. Schlessinger2 &
  • …
  • M. D. Waterfield1 

Nature volume 307, pages 521–527 (1984)Cite this article

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Abstract

Each of six peptides derived from the human epidermal growth factor (EGF) receptor very closely matches a part of the deduced sequence of the v-erb-B transforming protein of avian erythroblastosis virus (AEV). In all, the peptides contain 83 amino acid residues, 74 of which are shared with v-erb-B. The AEV progenitor may have acquired the cellular gene sequences of a truncated EGF receptor (or closely related protein) lacking the external EGF-binding domain but retaining the transmembrane domain and a domain involved in stimulating cell proliferation. Transformation of cells by AEV may result, in part, from the inappropriate acquisition of a truncated EGF receptor from the c-erb-B gene.

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Author information

Author notes
  1. P. Stockwell

    Present address: Department of Biochemistry, University of Otago, Dunedin, New Zealand

Authors and Affiliations

  1. Protein Chemistry Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, WC2A 3PX, UK

    J. Downward, E. Mayes, G. Scrace, N. Totty, P. Stockwell & M. D. Waterfield

  2. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

    Y. Yarden & J. Schlessinger

  3. Genentech Incorporated, 460 Point San Bruno Boulevard, San Francisco, California, 94080, USA

    A. Ullrich

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Downward, J., Yarden, Y., Mayes, E. et al. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature 307, 521–527 (1984). https://doi.org/10.1038/307521a0

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  • Received: 18 January 1984

  • Accepted: 23 January 1984

  • Issue date: 09 February 1984

  • DOI: https://doi.org/10.1038/307521a0

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