Abstract
Study design: Randomized controlled trial of physical exercise and dopaminergic agonist in persons with spinal cord injury and periodic leg movement (PLM).
Objective: The objective of the present study was to compare the effectiveness of physical exercise and of a dopaminergic agonist in reducing the frequency of PLM.
Setting: Centro de Estudos em Psicobiologia e Exercício. Universidade Federal de São Paulo, Brazil.
Methods: A total of 13 volunteers (mean age: 31.6±8.3 years) received L-DOPA (200 mg) and benserazide (50 mg) 1 h before sleeping time for 30 days and were then submitted to a physical exercise program on a manual bicycle ergometer for 45 days (3 times a week).
Results: Both L-DOPA administration (35.11–19.87 PLM/h, P<0.03) and physical exercise (35.11–18.53 PLM/h, P<0.012) significantly reduced PLM; however, no significant difference was observed between the two types of treatment.
Conclusions: The two types of treatment were found to be effective in the reduction of PLM; however, physical exercise is indicated as the first treatment approach, while dopaminergic agonists or other drugs should only be recommended for patients who do not respond to this type of treatment.
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We thank AFIP, CEPID (FAPESP Proc. no. 98/143033), Federal Government and the Sleep Institute/UNIFESP.
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de Mello, M., Esteves, A. & Tufik, S. Comparison between dopaminergic agents and physical exercise as treatment for periodic limb movements in patients with spinal cord injury. Spinal Cord 42, 218–221 (2004). https://doi.org/10.1038/sj.sc.3101575
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