Abstract
Study design:
Prospective experimental.
Objectives:
The aim of this study was to develop a quantitative sensory test (QST) that could be used for assessing the level and the density (degree of impairment) of spinal cord injury (SCI) and for monitoring neurological changes in patients with SCI.
Setting:
National Spinal Injuries Centre, Stoke Mandeville Hospital, Buckinghamshire Hospitals NHS Trust, UK.
Methods:
Perceptual threshold to 3 Hz cutaneous electrical stimulation was measured in 30 control subjects and in 45 patients with SCI at American Spinal Injuries Association (ASIA) sensory key points for selected dermatomes between C3 and S2 bilaterally. Electrical perceptual threshold (EPT) was recorded as the lowest ascending stimulus intensity out of three tests at which the subject reported sensation. The level of SCI according to EPT results was established for right and left sides as the most caudal spinal segment at which patient's EPT was within the control range (mean±2 standard deviation (SD)). The level of SCI, according to EPT, was then compared with clinical sensory level derived according to ASIA classification.
Results:
In the control group, EPT depended on the dermatome tested and was lowest for T1 (1.01±0.23 mA, mean±SD) and highest for L5 (3.32±1.14 mA). There was strong correlation between corresponding right and left dermatomes and between repeated assessments. In the SCI group, the level of lesion according to EPT and clinical testing was the same in 43 of the 90 tests (48%). In 37 cases (41%), the EPT level was higher than the clinical level, and in 10 cases (11%), it was lower. Below the level of lesion in incomplete SCI and in the zone of partial preservation in complete SCI, the EPT values in most dermatomes were raised compared with the control group.
Conclusions:
EPT is a simple, reproducible QST that can assess both the level and the density of SCI. It seems to add sensitivity and resolution to the standard clinical testing and could be a useful adjunct in longitudinal monitoring of patients with SCI for research purposes during natural recovery and therapeutic interventions.
Sponsorship:
International Spinal Research Trust (ISRT), UK, Grant CLI001.
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Acknowledgements
The Clinical Initiative Study was funded by The International Spinal Research Trust, UK, Grant CLI001. We thank all the patient and control volunteers for their generous participation in the study, the members of the Clinical Initiative team for their contribution to the work and the staff at the National Spinal Injuries Centre, Stoke Mandeville Hospital for their help during the study.
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Savic, G., Bergström, E., Frankel, H. et al. Perceptual threshold to cutaneous electrical stimulation in patients with spinal cord injury. Spinal Cord 44, 560–566 (2006). https://doi.org/10.1038/sj.sc.3101921
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DOI: https://doi.org/10.1038/sj.sc.3101921
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