Abstract
Children with the Beckwith-Wiedemann syndrome have a greatly increased potential for the specific development of the embryonal tumours hepatoblastoma, rhabdomyosarcoma and Wilms' tumour. Data obtained with molecular probes suggest that the association between these disparate, rare tumour types reflects a common pathogenetic mechanism that entails the somatic development of homozygosity for a mutant allele at a locus on human chromosome 11.
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References
Willis, R. A. Pathology of Tumours 4th edn 7–8 (Butterworth, London, 1967).
Nicholson, G. W. J path. Bact. 34, 711–730 (1931).
Warkany, J. Congenital Malformations 1199–1271 (Year Book, Chicago, 1971).
Best, L. G. & Hoekstra, R. E. Am. J. med. Genet. 9, 291–299 (1981).
Sotelo-Avila, C. & Gooch, W. M. Perspect. Pediat. Path. 3, 255–272 (1976).
Sotelo-Avila, C., Gonzalez-Cmssi, F. & Fowler, J. W. J. Pediat. 96, 47–50 (1980).
Muller, S., Gadner, H., Weber, B., Vogel, M. & Riehm, H. Eur. J. Pediat. 127, 219–226 (1978).
Riedel, H. A. Pediatrics 10, 19–27 (1952).
Miller, R. W., Fraumeni, J. F. & Manning, M. D. New Engl. J. Med. 270, 922–927 (1964).
Tefft, M., Vawter, G. F. & Mitus, A. Am. J. Roentg. 103, 800–822 (1968).
Milmun, D. H. & Grayzel, D. M. Am. J. Dis. Child. 81, 408–420 (1951).
Schweisgoth, O. Solid Tumors in Children (Wiley, New York, 1982).
Potter, E. L. Normal and Abnormal Development of the Kidney, 263 (Year Book, Chicago, 1972).
Wigger, H. J. Hum. Path. 7, 613–623 (1976).
Sheehan, H. L. J. path. Bact. 33, 251–258 (1930).
Wilkins, L. & Ravitch, M. M. Pediatrics 9, 671–681 (1952).
Pack, G. T. & Miller, T. R. AMA Archs Surg. 73, 1060–1062 (1956).
Koufos, A. et al. Nature 309, 170–172 (1984).
Orkin, S. H., Goldman, D. S. & Sallan, S. E. Nature 309, 172–174 (1984).
Reeve, A. E. et al. Nature 309, 174–176 (1984).
Fearon, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).
Cavenee, W. K. et al. Nature 305, 779–784 (1983).
Cavenee, W. K. et al. Science 228, 501–503 (1985).
Barker, D., Schafer, M. & White, R. Cell 36, 131–138 (1984).
Dracopoli, N. C. & Fogh, J. J natn. Cancer Inst. 70, 83–87 (1983).
Cavenee, W., Leach, R., Mohandas, T., Pearson, P. & White, R. Am. J. hum. Genet. 36, 10–24 (1984).
Wyman, A. R. & White, R. Proc. natn. Acad. Sci. U.S.A. 77, 6754–6758 (1980).
Skolnick, M. H., Willard, H. F. & Menlove, L. A. Cytogenet. Cell. Genet. 37, 210–273 (1984).
Riccardi, V. M., Sujansky, E., Smith, A. C. & Francke, U. Pediatrics 61, 604–610 (1978).
Turleau, C. et al. Hum. Genet. 67, 219–221 (1984).
White, R. et al. Nature 313, 101–105 (1985).
Gusella, J. F. et al. Science 225, 1320–1326 (1984).
Barker, D., Holm, T. & White, R. Am. J. hum. Genet. 36, 1159–1171 (1984).
Gerald, P. S. & Grzeschik, K. H. Cytogenet. Cell. Genet. 37, 103–126 (1984).
Bell, G. I., Selby, M. J. & Rutter, W. J. Nature 295, 31–35 (1982).
Goldfarb, M., Shimizu, K., Perucho, M. & Wigler, M. Nature 296, 404–409 (1982).
Antonarakis, S. E., Boehm, C. D., Giardina, P. J. & Kazazian, H. H. Proc. natn. Acad. Sci. U.S.A. 79, 137–141 (1982).
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Koufos, A., Hansen, M., Copeland, N. et al. Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism. Nature 316, 330–334 (1985). https://doi.org/10.1038/316330a0
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DOI: https://doi.org/10.1038/316330a0
