Abstract
The gene segments encoding the constant and variable regions of human immunoglobulin light chains of the κ type (Cκ, Vκ) have been localized to chromosome 2 (refs 1, 2). The distance between the Cκ and Vκ genes and the number of germline Vκ genes are unknown. As part of our work on the human Vκ locus (refs 3–6 and reviewed in ref. 7), we have now mapped two solitary Vκ gene and a cluster of three Vκ genes to chromosomes 1, 15 and 22, respectively. The three genes that have been sequenced are non-processed pseudogenes, and the same may be true for the other two genes. This is the first time that V-gene segments have been found outside the C-gene-containing chromosomes. Our finding is relevant to current estimates of the size of the Vκ-gene repertoire. Furthermore, the dispersed gene regions have some unusual characteristics which may help to clarify the mechanism of dispersion.
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Lötscher, E., Grzeschik, KH., Bauer, H. et al. Dispersed human immunoglobulin κ light-chain genes. Nature 320, 456–458 (1986). https://doi.org/10.1038/320456a0
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DOI: https://doi.org/10.1038/320456a0
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