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Pathogenesis of lentivirus infections

Abstract

Following infection of animals or humans, lentiviruses play a prolonged game of hide and seek with the host's immune system which results in a slowly developing multi-system disease. Emerging knowledge of the disease processes is of some relevance to acquired immune deficiency syndrome (AIDS), which is caused by a virus possessing many of the characteristics of a lentivirus.

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References

  1. Thormar, H. & Palsson, P. A. Perspect. Virol. 5, 291–308 (1967).

    Google Scholar 

  2. Gudnadottir, M. Prog. med. Virol. 18, 336–349 (1974).

    CAS  PubMed  Google Scholar 

  3. Haase, A. T. Curr. Topics Microbiol. Immun. 72, 101–156 (1975).

    CAS  Google Scholar 

  4. De Boer, G. F. Terpstra, C. & Houwers, D. J. Bull. Off. int. Epiz. 89, 487–506 (1978).

    Google Scholar 

  5. Brahic, M. & Haase, A. T. Comparative Diagnosis of Viral Diseases Vol. 4, Ch. 15 (Academic, New York, 1981).

    Google Scholar 

  6. Narayan, O. & Cork, L. C. Rev. infect. Dis. 7, 89–98 (1985).

    CAS  PubMed  Google Scholar 

  7. Nathanson, N. et al. Rev. infect. Dis. 7, 75–82 (1985).

    CAS  PubMed  Google Scholar 

  8. Coggins, L. Comparative Diagnosis of Viral Diseases Vol. 4, Ch. 16 (Academic, New York, 1981).

    Google Scholar 

  9. Cheevers, W. P. & McGuire, T. C. Rev. infect. Dis. 7, 83–88 (1985).

    CAS  PubMed  Google Scholar 

  10. Wong-Staal, F. & Gallo, R. C. Nature 317, 395–403 (1985).

    ADS  CAS  PubMed  Google Scholar 

  11. Sigurdsson, B., Palsso, P. A. & Crimson, H. J. Neuropath. exp. Neurol. 16, 389–403 (1957).

    CAS  PubMed  Google Scholar 

  12. Sigurdsson, B. & Palsson, P. A. Br. J. exp. Path. 39, 519–528 (1958).

    CAS  Google Scholar 

  13. Sigurdsson, B., Palsson, P. A. & Van Bogaert, L. Acta neuropath. 1, 343–362 (1962).

    Google Scholar 

  14. Georgsson, G., Palsson, P. A., Panitch, H., Nathanson, N. & Petursson, G. Acta neuropath. 37, 127–135 (1977).

    CAS  PubMed  Google Scholar 

  15. Georgsson, G. et al. Acta neuropath. 57, 171–178 (1982).

    CAS  PubMed  Google Scholar 

  16. Sigurdsson, B. Br. vet. J. 110, 255–270 (1954a).

    Google Scholar 

  17. Sigurdsson, B. Br. vet. J. 110, 341–354 (1954b).

    Google Scholar 

  18. Gajdusek, D. C. Science 197, 943–960 (1977).

    ADS  CAS  PubMed  Google Scholar 

  19. Petursson, G., Nathanson, N., Georgsson, G., Panitch, H. & Palsso, P. A. Lab. Invest. 35, 402–412 (1976).

    CAS  PubMed  Google Scholar 

  20. Griffin, D. E., Narayan, O. & Adams, R. J. J. infect. Dis. 138, 340–350 (1978).

    CAS  PubMed  Google Scholar 

  21. Haase, A. T., Stowring, L., Narayan, O., Griffin, D. & Price, D. Science 195, 175–177 (1977).

    ADS  CAS  PubMed  Google Scholar 

  22. Sigurdsson, B., Thormar, H. & Palsson, P. Arch. ges. Virusforsch. 10, 368–371 (1960).

    Google Scholar 

  23. Thormar, H. Virology 19, 273–278 (1963).

    CAS  PubMed  Google Scholar 

  24. Haase, A. T. & Varmus, H. E. Nature new Biol 245, 237–239 (1973).

    CAS  PubMed  Google Scholar 

  25. Haase, A. T., Traynor, B. L., Ventura, P. E. & Ailing, D. W. Virology 70, 65–79 (1976).

    CAS  PubMed  Google Scholar 

  26. Brahic, M., Filippi, P., Vigne, R. & Haase, A. T. J. Virol. 24, 74–81 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Harter, D. H. & Chopping, P. W. Virology 31, 279–288 (1967).

    CAS  PubMed  Google Scholar 

  28. Brahic, M., Stowring, L., Ventura, P. & Haase, A. T. Nature 292, 240–242 (1981).

    ADS  CAS  PubMed  Google Scholar 

  29. Haase, A., Brahic, M., Stowring, L. & Blum, H. Meth. Virol. 3, 189–226 (1984).

    Google Scholar 

  30. Haase, A. T. et al. Virology 140, 201–206 (1985).

    CAS  PubMed  Google Scholar 

  31. Harris, J. D. et al. Proc. natn. Acad. Sci. U.S.A. 81, 7212–7215 (1984).

    ADS  CAS  Google Scholar 

  32. Peluso, R., Haase, A., Stowring, L., Edwards, M. & Ventura, P. Virology 147, 231–236 (1985).

    CAS  PubMed  Google Scholar 

  33. Narayan, O. et al. J. gen. Virol. 59, 245–256 (1982).

    Google Scholar 

  34. Cutlip, R. C., Jackson, T. A. & Laird, G. A. Am. J. vet. Res. 38, 2091–2093 (1977).

    CAS  PubMed  Google Scholar 

  35. de Boer, G. F. & Houwers, D. J. in Aspects of Slow and Persistent Infections (ed. Tyrrell, D. A. J.) 198–221 (Elsevier, Amsterdam, 1979).

    Google Scholar 

  36. Hoxie, J. A., Haggarty, B. S., Rackowski, J. L., Pillsbury, N. & Levy, J. A. Science 229, 1400–1402 (1985).

    ADS  CAS  PubMed  Google Scholar 

  37. Folks, T. et al. Science 231, 600–602 (1986).

    ADS  CAS  PubMed  Google Scholar 

  38. Curran, J. W. et al. Science 229, 1352–1357 (1985).

    ADS  CAS  PubMed  Google Scholar 

  39. Barban, V. et al. J. Virol. 52, 680–682 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Panganiban, A. & Temin, H. Cell 36, 673–679 (1984).

    CAS  PubMed  Google Scholar 

  41. Harris, J. D. et al. Virology 113, 573–583 (1981).

    CAS  PubMed  Google Scholar 

  42. Shaw, G. M. et al. Science 226, 1165–1171 (1984).

    ADS  CAS  PubMed  Google Scholar 

  43. Rice, N. R., Simek, S., Ryder, O. A. & Coggins, L. J. Virol. 26, 577–583 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  44. Yaniv, A., Dahlberg, J. E., Tronick, S. R., Chiu, I.-M. & Aaronson, S. A. Virology 145, 340–345 (1985).

    CAS  PubMed  Google Scholar 

  45. Scott, J. V., Stowring, L., Haase, A. T., Narayan, O. & Vigne, R. Cell 18, 321–327 (1979).

    CAS  PubMed  Google Scholar 

  46. Narayan, O., Griffin, D. E. & Chase, J. Science 197, 376–378 (1977).

    ADS  CAS  PubMed  Google Scholar 

  47. Clements, J. E., Pederson, F. S., Narayan, O. & Haseltine, W. A. Proc. natn. Acad. Sci. U.S.A. 77, 4454–4458 (1980).

    ADS  CAS  Google Scholar 

  48. Lutley, R. et al. J. gen. Virol. 64, 1433–1440 (1983).

    PubMed  Google Scholar 

  49. Thormar, H., Barshatzky, M. R., Arnesen, K. & Kozlowski, P. B. J. gen. Virol. 64, 1427–1432 (1983).

    PubMed  Google Scholar 

  50. Kono, Y. Kobayashi & Fukunaga, Y. Arch. ges. Virusforsch. 41, 1–10 (1973).

    CAS  PubMed  Google Scholar 

  51. Salinovich, O. et al. J. Virol. 57, 71–80 (1986).

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Montelaro, R. C., Parekh, B., Orrego, A. & Issel, C. J. J. biol Chem. 259, 10539–10544 (1984).

    CAS  PubMed  Google Scholar 

  53. Wong-Staal, F. et al. Science 229, 759–762 (1985).

    ADS  CAS  PubMed  Google Scholar 

  54. Hahn, B. H. et al. Proc. natn. Acad. Sci. U.S.A. 82, 4813–4817 (1985).

    ADS  CAS  Google Scholar 

  55. Nathanson, N., Panitch, H., Palsson, P. A., Petursson, G. & Gorgsson, G. Lab. Invest. 35, 444–451 (1976).

    CAS  PubMed  Google Scholar 

  56. Stowring, L. et al. Virology 141, 311–318 (1985).

    CAS  PubMed  Google Scholar 

  57. Brahic, M., Haase, A. T. & Cash, E. Proc. natn. Acad. Sci. U.S.A. 81, 5445–5448 (1984).

    ADS  CAS  Google Scholar 

  58. Crawford, T. B., Adams, D. S., Cheevers, W. P. & Cork, L. C. Science 207, 997–999 (1980).

    ADS  CAS  PubMed  Google Scholar 

  59. Klevjer-Anderson, P., Adams, D. S., Anderson, L. W., Banks, K. L. & McGuire, T. C. J. gen. Virol. 65, 1519–1525 (1984).

    PubMed  Google Scholar 

  60. Jasin, H. E. & Dingle, J. T. J. clin. Invest. 68, 571–581 (1981).

    CAS  PubMed  PubMed Central  Google Scholar 

  61. McGuire, T. C. & Henson, J. B. in Progress in Medical Virology (ed. Hotchin, J.) 229–247 (Karger, New York, 1974).

    Google Scholar 

  62. Rao, T. K. et al. New Engl. J. Med. 310, 669–673 (1984).

    CAS  PubMed  Google Scholar 

  63. Cooper, D. A. et al. Lancet i, 537–540 (1985).

    Google Scholar 

  64. Shaw, G. M. et al. Science 227, 177–182 (1985).

    ADS  CAS  PubMed  Google Scholar 

  65. Epstein, L. G. et al. Ann. Neurol 17, 488–496 (1985).

    CAS  PubMed  Google Scholar 

  66. Price, R. W., Navia, B. A. & Cho, E.-S. Neurol Clin. 4, 285–301 (1986).

    CAS  PubMed  Google Scholar 

  67. Petito, C. K. et al. New Engl. J. Med. 312, 874–879 (1985).

    CAS  PubMed  Google Scholar 

  68. Gardner, M. Rev. infect. Dis. 7, 99–110 (1985).

    CAS  PubMed  Google Scholar 

  69. Seligmann, M. et al. New Engl. J. Med. 311, 1286–1291 (1984).

    CAS  PubMed  Google Scholar 

  70. Narayan, O., Sheffer, D., Griffin, D. E., Clements, J. & Hess, J. J. Virol. 49, 349–355 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Dalgleish, A. G. et al. Nature 312, 763–767 (1984).

    ADS  CAS  PubMed  Google Scholar 

  72. Klatzman, D. et al. Nature 312, 767–768 (1984).

    ADS  Google Scholar 

  73. Harper, M. E., Marselle, L. M., Gallo, R. C. & Wong-Staal, F. Proc. natn. Acad. Sci. U.S.A. 83, 772–776 (1986).

    ADS  CAS  Google Scholar 

  74. Williams, R. C. Jr, Masur, H. & Spira, T. J. J. clin. Immun. 4, 118–123 (1984).

    PubMed  Google Scholar 

  75. Klatzmann, D. & Montagnier, L. Nature 319, 10–11 (1986).

    ADS  CAS  PubMed  Google Scholar 

  76. Pahwa, S., Pahwa, R., Saxinger, C., Gallo, R. C. & Good, R. A. Proc. natn. Acad. Sci. U.S.A. 82, 8198–8202 (1985).

    ADS  CAS  Google Scholar 

  77. Mathes, L. E., Olsen, R. G., Hebebrand, L. C., Hoover, E. A. & Schaller, J. P. Nature 274, 687–689 (1978).

    ADS  CAS  PubMed  Google Scholar 

  78. Serwadda, D. et al. Lancet ii, 849–852 (1985).

    Google Scholar 

  79. Torti, F. M., Dieckmann, B., Beutler, B., Cerami, A. & Ringold, G. M. Science 229, 867–869 (1985).

    ADS  CAS  PubMed  Google Scholar 

  80. Temin, H. M., Keshet, E. & Weller, S. K. Cold Spring Harb. Symp. quant. Biol. 44, 773–778 (1980).

    CAS  PubMed  Google Scholar 

  81. Haase, A. T. et al. Virology 119, 399–410 (1982).

    CAS  PubMed  Google Scholar 

  82. Narayan, P., Clements, J. E., Griffin, D. E. & Wolinsky, J. S. Infect. Immunity 32, 1045–1050 (1981).

    CAS  Google Scholar 

  83. Geballe, A. P., Ventura, P., Stowring, L. & Haase, A. T. Virology 141, 148–154 (1985).

    CAS  PubMed  Google Scholar 

  84. Thormar, H. & Sigurdardottir, B. Acta path. microbiol. 55, 180–186 (1962).

    CAS  Google Scholar 

  85. Thormar, H., Wisniewski, H. M. & Lin, F. H. Nature 279, 245–256 (1979).

    ADS  CAS  PubMed  Google Scholar 

  86. Narayan, O., Griffin, D. E. & Silverstein, A. M. J. infect. Dis. 135, 800–806 (1977).

    CAS  PubMed  Google Scholar 

  87. Houwers, D. J. & Schaake, J. Jr Vet. Microbiol. 5, 445–451 (1984).

    Google Scholar 

  88. Filippi, P., Vigne, R., Querat, G., Jouanny, C. & Sauze, N. J. Virol. 42, 1057–1066 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Robert-Guroff, M., Brown, M. & Gallo, R. C. Nature 316, 72–74 (1985).

    ADS  CAS  PubMed  Google Scholar 

  90. Weiss, R. A. et al. Nature 316, 69–72 (1985).

    ADS  CAS  PubMed  Google Scholar 

  91. Zagury, C. et al. Science 226, 449–451 (1984).

    ADS  CAS  PubMed  Google Scholar 

  92. Groopman, J. E. et al. Science 226, 447–449 (1984).

    ADS  CAS  PubMed  Google Scholar 

  93. Levy, J. A. et al. Ann. intern. Med. 103, 694–699 (1985).

    CAS  PubMed  Google Scholar 

  94. Levy, J. A., Hollander, H., Shimabukuro, J., Mills, J. & Kaminsky, K. Lancet ii, 586–588 (1985).

    Google Scholar 

  95. Ho, D. D. et al. New Engl. J. Med. 313, 1493–1497 (1985).

    CAS  PubMed  Google Scholar 

  96. Resnick, L. et al. New Engl. J. Med. 313, 1498–1504 (1985).

    CAS  PubMed  Google Scholar 

  97. Haase, A. T. & Levinson, W. Biochem. biophys. Res. Commun. 51, 875–880 (1973).

    CAS  PubMed  Google Scholar 

  98. Sundquist, B. & Larner, E. J. Virol. 30, 847–851 (1977).

    Google Scholar 

  99. Carroll, D. et al. J. infect. Dis. 138, 614–617 (1978).

    CAS  PubMed  Google Scholar 

  100. Narayan, P., Sheffer, D., Clements, J. E. & Tennekoon, G. J. exp. Med. 162, 1954–1969 (1985).

    CAS  PubMed  Google Scholar 

  101. Broder, S. et al. Lancet ii, 627–630 (1985).

    Google Scholar 

  102. Mitsuya, H. et al. Proc. natn. Acad. Sci. U.S.A. 82, 7096–7100 (1985).

    ADS  CAS  Google Scholar 

  103. Sodroski, J. G. et al. Science 227, 171–173 (1985).

    ADS  CAS  PubMed  Google Scholar 

  104. Rosen, C. A., Sodroski, J. G. & Haseltine, W. A. Cell 41, 813–823 (1985).

    CAS  PubMed  Google Scholar 

  105. Arya, S. K., Guo, C., Josephs, S. F. & Wong-Staal, F. Science 229, 69–73 (1985).

    ADS  CAS  PubMed  Google Scholar 

  106. Rosen, C. A. et al. Nature 319, 555–559 (1986).

    ADS  CAS  PubMed  Google Scholar 

  107. Dayton, A. I., Sodroski, J. G., Rosen, C. A., Goh, W. C. & Haseltine, W. A. Cell 44, 941–947 (1986).

    CAS  PubMed  Google Scholar 

  108. Fisher, A. G. et al. Nature 320, 367–371 (1986).

    ADS  CAS  PubMed  Google Scholar 

  109. Hess, J. L., Clements, J. E. & Narayan, O. Science 229, 482–485 (1985).

    ADS  CAS  PubMed  Google Scholar 

  110. Sonigo, P. et al. Cell 42, 369–382 (1985).

    CAS  PubMed  Google Scholar 

  111. Sanchez-Pescador, R. et al. Science 227, 484–492 (1984).

    ADS  Google Scholar 

  112. Ratner, L. et al. Nature 313, 277–284 (1985).

    ADS  CAS  PubMed  Google Scholar 

  113. Muesing, M. A. et al. Nature 313, 450–458 (1985).

    ADS  CAS  PubMed  Google Scholar 

  114. Wain-Hobson, S., Sonigo, P., Danos, O., Cole, S. & Alizon, M. Cell 40, 9–17 (1985).

    CAS  PubMed  Google Scholar 

  115. Sodroski, J. et al. Science 231, 1549–1553 (1986).

    ADS  CAS  PubMed  Google Scholar 

  116. Narayan, O., Kennedy-Stoskopf, S., Sheffer, D., Griffin, D. E. & Clements, J. E. Infect. Immunity 41, 67–73 (1983).

    CAS  Google Scholar 

  117. Zagury, D. et al. Science 231, 850–853 (1986).

    ADS  CAS  PubMed  Google Scholar 

  118. Izant, J. G. & Weintraub, H. Science 229, 345–352 (1985).

    ADS  CAS  PubMed  Google Scholar 

  119. Coleman, J., Hirashima, A., Inokuchi, Y., Green, P. J. & Inouye, M. Nature 315, 601–603 (1985).

    ADS  CAS  PubMed  Google Scholar 

  120. Pestka, S., Daugherty, B. L., Jung, V., Hotta, K. & Pestka, R. K. Proc. natn. Acad. Sci. U.S.A. 81, 7525–7528 (1984).

    ADS  CAS  Google Scholar 

  121. Weiss, R., Teich, N., Varmus, H. & Coffin, J. (eds) RNA Tumor Viruses 2nd edn (Cold Spring Harbor Laboratory, New York, 1982).

  122. Haase, A. T. Microbiol. Pathogenesis 1, 1–4 (1986).

    CAS  Google Scholar 

  123. Gonda, M. A. et al. Science 227, 173–177 (1985).

    ADS  CAS  PubMed  Google Scholar 

  124. Roberson, S. M., McGuire, T. C., Klevjer-Anderson, P., Gorham, J. R. & Cheevers, W. P. J. Virol. 44, 755–758 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  125. Gogolewski, R. P., Adams, D. S., McGuire, T. C., Banks, K. L. & Cheevers, W. P. J. gen. Virol. 66, 1233–1240 (1985).

    CAS  PubMed  Google Scholar 

  126. Chiu, I.-M. et al. Nature 317, 366–368 (1985).

    ADS  CAS  PubMed  Google Scholar 

  127. Stowring, L., Haase, A. T. & Charman, H. P. J. Virol. 29, 523–528 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  128. Weiland, F., Matheka, H. D., Coggins, L. & Hartner, D. Archs Virol. 55, 335–340 (1977).

    CAS  Google Scholar 

  129. Stephens, R. M., Casey, J. W. & Rice, N. R. Science 231, 589–594 (1986).

    ADS  CAS  PubMed  Google Scholar 

  130. Montagnier, L. et al. Virology 144, 283–289 (1985).

    CAS  PubMed  Google Scholar 

  131. Barin, F. et al. Science 228, 1091–1096 (1985).

    ADS  PubMed  Google Scholar 

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Haase, A. Pathogenesis of lentivirus infections. Nature 322, 130–136 (1986). https://doi.org/10.1038/322130a0

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