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Genetically modified immunocompetent cells in HIV infection

Gene Therapy volume 8, pages 1593–1600 (2001)Cite this article

Abstract

Even in the era of highly active antiretroviral therapy (HAART), gene therapy (GT) can remain a promising approach for suppressing HIV infection, especially if complemented with other forms of pharmacological and immunological intervention. A large number of vectors and targets have been studied. Here we discuss the potential of genetically treated, antigen-specific immunocompetent cells for adoptive autologous immunotherapy of HIV infection. Cellular therapies with gene-modified CD8 and CD4 lymphocytes are aimed at reconstituting the antigen-specific repertoires that may be deranged as a consequence of HIV infection. Even if complete eradication of HIV from the reservoirs cannot be achieved, reconstitution of cellular immunity specific for opportunistic pathogens and for HIV itself is a desirable option to control progression of HIV infection and AIDS pathogenesis better.

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Acknowledgements

This work was supported by grants to G Palù (National Health Institute, Rome, AIDS Project N.40B.72, Fondazione Cassa di Risparmio di Padova e Rovigo, MURST, CNR Target Project on Biotechnology), to C Parolin (National Health Institute, Rome, AIDS Project N.30C.57) and to F Manca (National Health Institute, Rome, AIDS Project N.40A.0.64 and Tuberculois Project 99/D/T; National Research Council, Rome – Biotechnology Project 1999; European Union Contracts – CA BHH4-CT9720, FAIR CT97-3046, QLRT-1999-31041, QLK2-1999-01040, QLK2-CT1999-01321). The authors thank M Guida for artwork.

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  1. Department of Histology, Microbiology and Medical Biotechnologies, University of Padua, Padua, Italy

    G Palù, F Gennari & C Parolin

  2. Unit of Viral Immunology, Advanced Biotechnology Center, Genoa, Italy

    GLi Pira, D Fenoglio & F Manca

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  1. G Palù
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Palù, G., Pira, G., Gennari, F. et al. Genetically modified immunocompetent cells in HIV infection. Gene Ther 8, 1593–1600 (2001). https://doi.org/10.1038/sj.gt.3301569

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