Abstract
We have previously shown that a mixture of three synthetic peptides (83.1, 55.1, 35.1), corresponding to fragments of the relative molecular mass 83,000 (83K), 55K and 35K Plasmodium falciparum merozoite-specific proteins, induces protection in Aotus trivirpatus monkeys experimentally infected with P. falciparum1,2. Here we describe two polymeric synthetic hybrid proteins based on these peptides that delay or suppress the development of parasitaemia in immunized human volunteers.
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References
Patarroyo, M. E. et al. Nature 328, 629–632 (1987).
Patarroyo, M. E. et al. in Vaccines 87 (eds Chanock, R. M., Lerner, R. A., Brown, E. & Ginsberg, H.) 117–124 (Cold Spring Harbor Laboratory, New York, 1987).
Zavala, F. et al. Science 228, 1436–1440 (1985).
Good, M. F. et al. Science 235, 1059–1062 (1987).
Collins, W. E. et al. Nature 323, 259–262 (1986).
WHO International Digest of Health Legislation 36, 825–829 (1985).
TDR. Document TDR/IMMAL/FIELDMAL/VAC 85.3.
Hersenberg, H. & Tukuhisa, T. J. exp. Med. 155, 1730–1740 (1982).
Schutz, M. P., Leclerc, C., Audibert, F. & Chedid, L. J. Immun. 135, 2319–2322 (1985).
Ballou, W. R. et al. Lancet i, 1277–1281 (1987).
Herrington, D. A. et al. Nature 328, 257–259 (1987).
Barany, G. & Merrifield, R. B., The Peptides (eds Gross, E. & Meinhofer, J.) Vol. 2, 1–284 (Academic Press, New York, 1980).
Sarin, V. K., Kent, S. B. H., Tam, J. P. & Merrifield, R. B., Analyt. Biochem. 117, 147–157 (1981).
Tam, J. P., Heath, W. F. & Merrifield R. B. Int. J. Peptide Protein Res. 21, 57–65 (1983).
Perlmann, H. et al. J. exp. Med. 159, 1686–1704 (1984).
Robertson, P. W., Wybin, L. R. & Cox, J. J. immun. Meth. 76, 195–197 (1985).
Troye-Blomberg, M., Perlmann, H. K., Patarroyo, M. E. & Perlmann, P. Clin. exp. Immun. 53, 345–353 (1983).
Troye-Blomberg, M., Romero, P., Patarroyo, M. E., Björkman, A. & Perlman, P., Clin. exp. Immun. 58, 380–387 (1984).
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Patarroyo, M., Amador, R., Clavijo, P. et al. A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria. Nature 332, 158–161 (1988). https://doi.org/10.1038/332158a0
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DOI: https://doi.org/10.1038/332158a0
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