Abstract
Immunoglobulin A is the primary immunoglobulin isotype in tears, saliva, breast milk and other mucosal secretions, constituting between 6% and 15% of the total serum immunoglobulins1. Human peripheral blood neutrophils have IgA receptors, but these cells do not normally participate in IgA-mediated phagocytosis. The haematopoietic factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) prime neutrophils to be more responsive to a variety of stimuli2–4. We therefore studied their effect on IgA-mediated phagocytosis. GM-CSF and G-CSF both induce a change from low to high-affinity neutrophil IgA Fc crystallizable fragment receptors within 30min; a change which is associated with the development of IgA-mediated phagocytosis. Human IL-3, which does not affect neutrophil function, is inactive in this sytem. These results define a new mechanism for CSF-agumented host defence whereby neutrophil function can be modulated by CSF-mediated IgA Fc receptor activation.
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References
Conley, M. E. & Delacroix, D. L. Ann. intern. Med. 106, 892–899 (1987).
Weisbart, R. H., Golde, D. W., Clark, S. C., Wong, G. C. & Gasson, J. C. Nature 314, 361–363 (1985).
Weisbart, R. H., Kwan, L., Golde, D. W. & Gasson, J. C. Blood 69, 18–21 (1987).
Lopez, A. F. et al. J. Immunol. 131, 2983–2988 (1981).
Klebanoff, D. J. & Clark, R. A. The Neutrophil: Function and Clinical Disorders (North-Holland, Amsterdam, New York, Oxford, 1978).
Quie, P. G., Messner, R. P. & Williams, R. C. Jr J. exp. Med. 128, 553–570 (1968).
Wilson, J. D. J. Immunol. 108, 726–730 (1972).
Zipursky, A., Brown, E. J. & Bienenstock, J. Proc. Soc. exp. Biol. (N. Y.) 142, 181–184 (1973).
Fanger, M. W., Goldstine, S. N. & Shen, L. Molec. Immunol 20, 1019–1027 (1983).
Weisbart, R. H., Golde, D. W. & Gasson, J. C. J. Immunol. 137, 3584–3587 (1986).
Gasson, J. C., Kaufman, S. E., Weisbart, R. H., Tomonaga, M. & Golde, D. W. Proc. natn. Acad. Sci. U.S.A. 83, 669–673 (1986).
Calvo, J. C., Radicella, J. P. & Charreau, E. H. Biochem. J. 212, 259–264 (1983).
Tagliabue, A. et al. J. Immunol. 133, 988–992 (1984).
Tagliabue, A., Villa, L., Boraschi, K., Peri, G., deGori, V. & Nencioni, L. J. Immunol. 135, 4178–4182 (1985).
Maliszewski, C. R., Shen, L. & Fanger, M. W. J. Immunol. 135, 3878–3881 (1985).
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Weisbart, R., Kacena, A., Schuh, A. et al. GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism. Nature 332, 647–648 (1988). https://doi.org/10.1038/332647a0
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DOI: https://doi.org/10.1038/332647a0
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