Abstract
In mice, two sets of genes govern the immune response to the synthetic antigen GT. One maps to the major histocompatibility complex and behaves like a typical immune response gene. The second is a background gene encoding a cell surface structure found on B cells. Mice which express, and are therefore tolerant of, one form of this structure do not respond to GT. Thus, tolerance of self generates holes in the T-cell repertoire, partially crippling the immune system.
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References
Benacerraf, B. & McDevitt, H. O. Science 175, 273–279 (1972).
Schwartz, R. H. Adv. Immun. 38, 31–201 (1986).
Blomberg, B., Geckeler, W. R. & Weigert, M. Science 177, 178–180 (1972).
Cohn, M. et al. in The Immune System, Genes, Receptors, Signals (eds Sercarz, E. E., Williamson, A. R. & Fox, C. F.), 89–117 (Academic, New York, 1974).
Epstein et al. J. exp. Med. 163, 759–773 (1986).
Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).
Babbitt, B., Allen, P. M., Matsueda, G., Haber, E. & Unanue, E. R. Nature 317, 359–361 (1985).
Billingham, R. E., Brent, L. & Medawar, P. B. Phil. Trans. R. Soc. Lond. 239, 357–414 (1956).
Schwartz, R. H. Scand. J. Immun. 7, 3–10 (1978).
Matzinger, P. Nature 292, 497–501 (1981).
Clark, R. B. & Schevach, E. M. J. exp. Med. 155, 635–640 (1982).
Dos Reis, G. A. & Schevach, E. M. J. exp. Med. 157, 1287–1299 (1983).
Ishii, N., Nagy, Z. A. & Klein, J. J. exp. Med. 157, 998–1005 (1983).
Vidović, D., Klein, J. & Nagy, Z. A. J. Immun. 134, 3563–3568 (1985).
Taylor, B. A. in Origin of Inbred Mice (ed. Morse, H. C.) 423–438 (Academic, New York, 1978).
Dembić, Z., Bannwarth, W., Taylor, B. A. & Steinmetz, M. Nature 314, 271–273 (1985).
Lee, N. E. et al. J. exp. Med. 160, 905–913 (1984).
Marrack, P. & Kappler, J. Nature 32, 840–843 (1988).
Urba, W. J. & Hildemann, W. H. Immunogeneties 6, 433–445 (1978).
Zaleski, M. B. Immunogenetics 3, 226–238 (1974).
Debré, P., Waltenbaugh, C., Dorf, M. & Benacerraf, B. J. exp. Med. 144, 272–276 (1976).
Debré, P., Kapp, J. A., Dorf, M. E. & Benacerraf, B. J. exp. Med. 142, 1447–1454 (1975).
Cinader, B., Koh, S. W. & Naylor, D. Int. Archs Allergy appl. Immun. 35, 150–162 (1962).
Dorsch, S. & Roser, B. Nature 258, 233–235 (1975).
Gorczynski, R. M. & MacRae, S. J. Immun. 122, 747–752 (1979).
Prud'homme, G. J. et al. Immunol. Today 6, 160–162 (1985).
Prochazka, M., Leiter, E. H., Serreze, D. V. & Coleman, D. L. Science 237, 286–289 (1987).
Gasser, D. L. & Shreffler, D. C. Immunogenetics 1, 133–140 (1974).
Botazzo, G. F. et al. Immunol. Rev. 94, 137–169 (1986).
Cohen, I. R. Immunol. Rev. 94, 5–21 (1986).
Du Pasquier, L. & Blomberg, B. Immunogenetics 15, 251–260 (1982).
Du Pasquier, L. et al. Immunogenetics 5, 129–141 (1977).
Köhler, G. & Milstein, C. Nature 256, 495–497 (1975).
Marrack, P. in Isolation, Characterization and Utilisation of T Lymphocyte Clones (eds Fathman, C. G. & Fitch, F. W.) 508–510 (Academic, New York, 1982).
Pierrés, A. et al. J. Immun. 132, 2775–2782 (1984).
Pierrés, M., Devaux, C., Dosseto, M. & Marchetto, S. Immunogenetics 14, 481–485 (1981).
Pierrés, M., Goridis, C. & Golstein, P. Eur. J. Immun. 12, 60–69 (1982).
Naquet, P., Marchetto, S. & Pierrés, M. Immunogenetics 18, 559–574 (1983).
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Vidović, D., Matzinger, P. Unresponsiveness to a foreign antigen can be caused by self-tolerance. Nature 336, 222–225 (1988). https://doi.org/10.1038/336222a0
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DOI: https://doi.org/10.1038/336222a0
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