Genetic manipulation of mammalian cells has provided a means of producing unlimited quantities of a high purity, virus-free preparation of factor VIM — the most complex protein manufactured through rDNA technology to date.
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Kaufman, R. Genetic engineering of factor VIII. Nature 342, 207–208 (1989). https://doi.org/10.1038/342207a0
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DOI: https://doi.org/10.1038/342207a0
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