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In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs

Nature volume 344, pages 126–132 (1990)Cite this article

Abstract

Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for telomerase in vivo.

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Author notes

  1. Elizabeth H. Blackburn: To whom correspondence should be addressed.

Authors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720, USA

    Guo-Liang Yu, John D. Bradley, Laura D. Attardi & Elizabeth H. Blackburn

Authors
  1. Guo-Liang Yu
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  2. John D. Bradley
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  3. Laura D. Attardi
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  4. Elizabeth H. Blackburn
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Yu, GL., Bradley, J., Attardi, L. et al. In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature 344, 126–132 (1990). https://doi.org/10.1038/344126a0

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  • DOI: https://doi.org/10.1038/344126a0

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