Abstract
INTERACTION with antigen-presenting accessory cells is thought to be an important step in B-cell activation1–5, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response6. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
1. Mornssey P J Boswell H S Scher I & Singer A J Immun 127, 1345-1347 (1981) 2. Kincaide P W Adv Immun 41, 181-267 (1987) 3. Hemen E & Tsunoda R Immun Today 8, 142-144 (1987) 4. Boswell H S Sharrow S O & Singer A J Immun 124, 989 995 (1980) 5. Jehnek D F & Lipsky P Adv Immun 40, 1-59 (1987) 6. Pezzutto A Rabmovitch P S Dorken B Moldenhauer G & Clark E A J Immun 140,1791-1795 (1988) 7. Dorken B et al J Immun 136, 4470-4479 (1986) 8. Seed B & Aruffo A Proc natn Acad Sei USA 84, 3365 3369 (1987) 9. Aruffo A & Seed B Proc natn Acad Sei USA 84, 8573-8577 (1987) 10. Moldenhauer G et al m Leukocyte Typing IV (ed Knapp W ) (Oxford University Press m the press) 11. Dorken B er al m Leukocyte Typing III (ed McMichael A J ) 369-373 (Oxford University Press 1987) 12. Kozak M Nucleic Acids Res 12, 857-872 (1984) 13. von Heijne G Nucleic Acids Res 14, 4683-4690 (1986) 14. Williams A F Immun Today 8, 298-303 (1987) 15. Arquint M et al Proc natn Acad Sei USA 84,600-604(1987) 16. Lai C Étal Proc natn Acad Sei USA 84, 4337-4341 (1987) 17. Salzer J L Holmes W P & Coleman D R J Cell Biol 104, 957-965 (1987) 18. Lai C Watson J B Bloom F E Sutchffe J G & Milner R J Immun Rev 100,129-151 (1987) 19. Dayhoff M 0 Barker W C & Hunt L T Meth Enzym 91, 524-545 (1983) 20. Stamenkovic l Clark E A & Seed B EMBO J 8, 1403-1410 (1989) 21. McGraw D J Kurec A S & Davey F R Am J dm Pathol 77, 177-183 (1982) 22. Eremm O & Bmns R M Immunology 47, 321-327 (1982) 23. Davey F R Kurec A S & Lamberson H V Clin exp Immunol 54, 771-777 (1983) 24. Zalewski P D Valente L & Forbes l J J Immun 132, 2491-2495 (1984) 25. Ito S & Lawton A R J Immun 133, 1891-1895 (1984) 26. Pezzutto A Dorken B Moldenhauer G & Clark E A J Immun 138, 98-103 (1987) 27. Shen G L ef al J natn Cancer Inst 42, 792-797 (1988)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stamenkovic, I., Seed, B. The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 345, 74–77 (1990). https://doi.org/10.1038/345074a0
Received:
Accepted:
Issue date:
DOI: https://doi.org/10.1038/345074a0
This article is cited by
-
Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA
Nature Communications (2020)
-
Clinical trials of dual-target CAR T cells, donor-derived CAR T cells, and universal CAR T cells for acute lymphoid leukemia
Journal of Hematology & Oncology (2019)
-
Clinical trial update on bispecific antibodies, antibody-drug conjugates, and antibody-containing regimens for acute lymphoblastic leukemia
Journal of Hematology & Oncology (2019)
-
Inotuzumab ozogamicin in clinical development for acute lymphoblastic leukemia and non-Hodgkin lymphoma
Biomarker Research (2019)
-
CD22-Binding Peptides Derived from Anti-CD22 Ligand Blocking Antibodies Retain the Targeting and Cell Killing Properties of the Parent Antibodies and May Serve as a Drug Delivery Vehicle
International Journal of Peptide Research and Therapeutics (2008)
