Abstract
LONG-TERM potentiation (LTP) of excitatory synaptic transmission1–4 could be a mechanism underlying memory3,5. Induction of LTP requires Ca2+ influx into postsynaptic neurons6 through ion channels gated by NMDA (N-methyl-D-aspartate) receptors in hippocampus (area CA17,8 and dentate gyrus9) and neocortex10. Here we report that a component of LTP not requiring the activation of NMDA receptors can be induced in area CA1. The component is dependent on tetanus frequency, requires increases in postsynaptic intracellular Ca2+ concentrations, and is suppressed by an antagonist of voltage-dependent Ca2+ channels.
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Grover, L., Teyler, T. Two components of long-term potentiation induced by different patterns of afferent activation. Nature 347, 477–479 (1990). https://doi.org/10.1038/347477a0
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DOI: https://doi.org/10.1038/347477a0
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