Use of the SCID-hu mouse — an immunodeficient mouse transplanted with relevant organs of the human immune system — as a preclinical testing system for human therapeutics is discussed.
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References
McCune, J. M. et al. Science 241, 1632–1639 (1988).
McCune, J.M., Kaneshima, H., Lieberman, M., Weiss-man, I.L. & Namikawa, R. in Curr. Topics Microbiol. Immunol. Vol. 152 (eds Bosnia, M. J., Phillips, R. A. & Schuler, W.) 183–193 (Springer, Berlin, 1989).
McCune, J.M. in Semin. Virol. Vol. 1 (ed. Chen, I. S. Y.) 229–235 (W. B. Saunders, Philadelphia, 1990).
McCune, J. M. in Human Retroviruses Vol. 119 (eds Groop-man, J. E., Chen, I. S. Y., Essex, M. & Weiss, R. A.) 347–359 (Wiley, New York, 1990).
Namikawa, R., Kaneshima, H., Lieberman, M., Weiss-man, I.L. & Mc Cune, J.M. Science 242, 1684–1686 (1988).
McCune, J.M., Namikawa, R., Shih, C-C., Rabin, L. & Kaneshima, H. Science 247, 564–566 (1990).
Namikawa, R., Fedor, J., Kaneshima, H. & Mc Cune, J.M. in 6th int. Conf. AIDS Vol. 1, 194 (1990).
Kaneshima, H., Shih, C-C., Namikawa, R., Rabin, L. & McCune, J.M. (submitted).
Rabin, L., Kaneshima, H., Shih, C-C. & Mc Cune, J.M. in 6th int. Conf. AIDS Vol. 3, 113 (1990).
Kaneshima, H., Shih, C-C., Namikawa, R., Rabin, L. & McCune, J. M. in 6th int. Conf. AIDS Vol. 3, 99 (1990).
McCune, J. M., Shih, C-C., Namikawa, R., Rabin, L. & Kaneshima, H. in 6th int. Conf. AIDS Vol. 2, 107 (1990).
Shih, C.-C. et al. J. infect. Dis. (in the press).
Namikawa, R., Weilbaecher, K. N., Kaneshima, H., Yee, E. J. & McCune, J. M. J. exp. Med. 172, 1055–1063 (1990).
Peault, B., Weissman, I. L. – Baum, C., McCune, J. M. & Tsukamoto, A. (submitted).
Krowka, J., Sarin, S., Namikawa, R., McCune, J. M. & Kaneshima, H. in 6th int. Conf. AIDS Vol. 1, 194 (1990).
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Kaneshima, H., Baum, C., Chen, B. et al. Today's SCID-hu mouse. Nature 348, 561–562 (1990). https://doi.org/10.1038/348561a0
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DOI: https://doi.org/10.1038/348561a0
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