Figure 1: The nature of TCR interaction with peptide–MHC ligand. | Nature

Figure 1: The nature of TCR interaction with peptide–MHC ligand.

From: Selecting and maintaining a diverse T-cell repertoire

Figure 1

a, Positioning of the three CDR loops of the TCRα and TCRβ chains in the ligand-binding face of the TCR. b, Footprint of the TCR on the peptide–MHC complex. c, MHC class I molecule with bound peptide. The long α-helices of MHC enclose the peptide. Reprinted with permission from Garcia et al.11. The crystal structure of a TCR interaction with a MHC class II ligand has not been reported but is likely to follow the same rules.

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