Abstract
When a system approaches a critical point, strong fluctuations develop on every scale, from molecules to the entire system. Here we show that critical fluctuations in the domains in a lipid monolayer can be captured and measured by immobilizing it on a solid support and visualizing the pattern using atomic-force microscopy. Such fluctuations in physical properties may reflect the nanometre-scale domain organization in the lipid-bilayer component of biological membranes.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others
References
Stanley, H. E. Rev. Mod. Phys. 71, S358–S366 (1999).
Andrews, T. Phil. Trans. R. Soc. Lond. 159, 575– 590 (1869).
Albrecht, O., Gruler, H. & Sackmann, E. J. Phys. (Paris) 39, 301– 313 (1978).
Knobler, C. M. & Schwartz, D. K. Curr. Opin. Colloid Interface Sci. 4, 46–51 ( 1999).
Nielsen, L. K., Bjørnholm, T. & Mouritsen, O. G. J. Phys. Cond. Mat. 12, 309–314 (2000).
Mouritsen, O. G. & Andersen, O. S. (eds) Biol. Skr. Kgl. Dan. Vid. Selsk. 49, 1–214 (1998).
Hønger, T. et al. Biochemistry 35, 9003– 9006 (1996).
Mustonen, P. et al. Biochemistry 26, 2991– 2997 (1987).
Mouritsen, O. G. & Jørgensen, K. Curr. Opin. Struct. Biol. 7, 518–527 (1997).
Edidin, M. Curr. Opin. Struct. Biol. 7, 528–532 (1997).
Korlach, J., Schwille, P., Webb, W. W. & Feigenson, G. W. Proc. Natl Acad. Sci. USA 96, 8461– 8466 (1999).
Simons, K. & Ikonen, E. Nature 387, 569–572 (1997).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nielsen, L., Bjørnholm, T. & Mouritsen, O. Fluctuations caught in the act. Nature 404, 352 (2000). https://doi.org/10.1038/35006162
Issue date:
DOI: https://doi.org/10.1038/35006162
This article is cited by
-
Critical fluctuations and slowing down of chaos
Nature Communications (2019)
-
The Vapour-Vapour Interface Observation and Appraisement of a Gas-Condensate/Supercritical CO2 System
Scientific Reports (2018)
-
Critical Fluctuations of Membranes: Spectroscopy Meets Thermodynamics
International Journal of Thermophysics (2013)
-
Protein sorting and membrane-mediated interactions
Biophysical Reviews (2012)


