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Jumping the gun on mouse gene expression

Nature volume 405, page 733 (2000)Cite this article

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Sir

I am writing to correct a statement in the informative News Feature “A silence that speaks volumes” (Nature 404, 804; 2000). The work from my laboratory, published in the paper by Florence Wianny and myself, has shown that dsRNA interference can be effective in both the mouse oocyte and early embryo (see Wianny, F. & Zernicka-Goetz, M. Nature Cell Biol. 2, 70–75; 2000). We have successfully used the technique to prevent expression of the c-mos gene during oocyte maturation, and of the E-cadherin gene to interfere with formation of the blastocyst when delivered to the one-cell-stage zygote.

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  1. Wellcome/CRC Institute, Tennis Court Road, Cambridge, CB2 1QR, UK

    Magdalena Zernicka-Goetz

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  1. Magdalena Zernicka-Goetz
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Zernicka-Goetz, M. Jumping the gun on mouse gene expression. Nature 405, 733 (2000). https://doi.org/10.1038/35015787

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