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Cell differentiation

Hepatocytes from non-hepatic adult stem cells

Nature volume 406, page 257 (2000)Cite this article

Abstract

Stem cells are undifferentiated long-lived cells that are capable of many rounds of division. Here we show that adult human liver cells can be derived from stem cells originating in the bone marrow or circulating outside the liver, raising the possibility that blood-system stem cells could be used clinically to generate hepatocytes for replacing damaged tissue.

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Figure 1: Photomicrographs showing the presence of the Y chromosome, detected by immunolocalization of a fluorescein isothiocyanate (FITC)-labelled Y-chromosome probe using an anti-fluorescein antibody conjugated to horseradish peroxidase, and visualized using diaminobenzidine as a brown chromogen.

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Authors and Affiliations

  1. Department of Histopathology, Imperial College School of Medicine, Hammersmith Campus, London, W12 0NN, UK

    Malcolm R. Alison, Joe Jacob & Nicholas A. Wright

  2. Histopathology Unit, Imperial Cancer Research Fund, London, WC2A 3PX, UK

    Richard Poulsom, Rosemary Jeffery & Nicholas A. Wright

  3. Department of Histopathology, Royal Free Campus, Royal Free and University College School of Medicine, London, NW3 2PF, UK

    Amar P. Dhillon & Alberto Quaglia

  4. Department of Haematology, Royal Free Campus, Royal Free and University College School of Medicine, London, NW3 2PF, UK

    Grant Prentice

  5. Department of Histopathology, University College London, London, WC1E 6JJ, UK

    Marco Novelli

  6. Human Cytogenetics Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, UK

    Jill Williamson

Authors
  1. Malcolm R. Alison
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  2. Richard Poulsom
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  3. Rosemary Jeffery
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  4. Amar P. Dhillon
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  5. Alberto Quaglia
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  6. Joe Jacob
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  7. Marco Novelli
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  8. Grant Prentice
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  9. Jill Williamson
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  10. Nicholas A. Wright
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Corresponding author

Correspondence to Malcolm R. Alison.

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Alison, M., Poulsom, R., Jeffery, R. et al. Hepatocytes from non-hepatic adult stem cells. Nature 406, 257 (2000). https://doi.org/10.1038/35018642

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