Figure 3: RhoC regulates melanoma cell chemotaxis and invasion.
From: Genomic analysis of metastasis reveals an essential role for RhoC
a, Poorly (P) or highly metastatic (M) A375 cells expressing rhoC, rhoA or dominant-negative (dn) rho were induced to migrate towards serum for 16 h. Over 25% of the plated A375M cells migrated within this time. Each bar represents the mean ± s.e.m. of four experiments done in duplicate. b, The cell lines described above were induced to invade matrigel-coated membranes for 48 h. Over 30% of the plated A375M cells invaded within this time. Each bar represents the mean ± s.e.m. of three experiments done in duplicate.
