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New use of BCG for recombinant vaccines

Nature volume 351, pages 456–460 (1991)Cite this article

Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

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Author information

Author notes

  1. M. H. Lee and G. F. Hatfull: Division of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA

  2. S. B. Snapper, R. G. Barletta, W. R. Jacobs and B. R. Bloom: Howard Hughes Medical Institute, Albert Einstein College of Medicine, Bronx, New York 10461, USA

Authors and Affiliations

  1. Medlmmune Incorporated, Gaithersburg, Maryland, 20878, USA

    C. K. Stover, V. F. de la Cruz, T. R. Fuerst, J. E. Burlein, L. A. Benson, L. T. Bennett, G. P. Bansal, J. F. Young, M. H. Lee, G. F. Hatfull, S. B. Snapper, R. G. Barletta, W. R. Jacobs Jr & B. R. Bloom

Authors
  1. C. K. Stover
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  2. V. F. de la Cruz
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  3. T. R. Fuerst
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  4. J. E. Burlein
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  5. L. A. Benson
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  6. L. T. Bennett
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  7. G. P. Bansal
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  8. J. F. Young
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  9. M. H. Lee
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  10. G. F. Hatfull
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  11. S. B. Snapper
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  12. R. G. Barletta
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  13. W. R. Jacobs Jr
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  14. B. R. Bloom
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Stover, C., de la Cruz, V., Fuerst, T. et al. New use of BCG for recombinant vaccines. Nature 351, 456–460 (1991). https://doi.org/10.1038/351456a0

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