Abstract
IN mice transgenic for an autoantibody, self-reactive B cells have been shown to be eliminated upon interaction with membrane-bound self-antigens in the periphery1,2as well as in the bone marrow3–5, suggesting that both immature and mature B cells are eliminated by multimerization of surface immunoglobulins (sIg). Activation of mature B cells by antigens may thus require a second signal that inhibits sIg-mediated apoptosis. Such a second signal is likely to be provided by T helper cells, because B-cell tolerance is more easily induced in the absence of T helper cells6–9. To assess the molecular nature of the signal that inhibits slg-mediated apoptosis, we used anti-IgM-induced apoptotic death of WEHI-231 B lymphoma cells10,11 as a model system. Here we report that the signal for abrogating sIg-mediated apoptosis is generated by association of the CD40L molecule on T cells with the CD40 molecule on WEHI-231 cells. T-cell help through CD40 may thus determine whether B cells are eliminated or activated upon interaction with antigens.
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Tsubata, T., Wu, J. & Honjo, T. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40. Nature 364, 645–648 (1993). https://doi.org/10.1038/364645a0
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DOI: https://doi.org/10.1038/364645a0
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