Table 3 Main functional role of the identified genes
From: Genome-wide gene-expression patterns of donor kidney biopsies distinguish primary allograft function
Gene symbol | Gene name | UniGene ID | Expression | |
|---|---|---|---|---|
CAD | LIV | |||
Complement system | ||||
BF | B-factor, properdin | Hs.69771 | 2.57 | −0.48 |
C1R | complement component 1, r subcomponent | Hs.1279 | 2.23 | −0.54 |
C2 | complement component 2 | Hs.2253 | 0.31 | −2.28 |
C1S | complement component 1, s subcomponent | Hs.169756 | 2.49 | 0.82 |
CLU | clusterin | Hs.75106 | 0.54 | −0.91 |
Immune response | ||||
LTF | lactotransferrin | Hs.105938 | 3.46 | 1.16 |
NK4 | natural killer cell transcript 4 | Hs.943 | 2.01 | 0.11 |
VCAM1 | vascular cell adhesion molecule 1 | Hs.109225 | 5.33 | 3.65 |
IL1R1 | interleukin 1 receptor, type I | Hs.82112 | 2.83 | 1.19 |
HLA-G | HLA-G histocompatibility antigen, class I, G | Hs.73885 | 0.34 | −1.26 |
IFITM2 | interferon-induced transmembrane protein 2 (1-8D) | Hs.174195 | 1.02 | −0.52 |
IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) | Hs.177559 | 1.27 | −0.27 |
B2M | beta-2-microglobulin | Hs.48516 | 3.13 | 1.81 |
HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | Hs.73931 | 1.43 | 0.14 |
BCL6 | B-cell CLL/lymphoma 6 (zinc finger protein 51) | Hs.155024 | 0.71 | −0.54 |
Metabolism (amino acid) | ||||
GPX2 | glutathione peroxidase 2 (gastrointestinal) | Hs.2704 | 1.81 | −1.64 |
HPD | 4-hydroxyphenylpyruvate dioxygenase | Hs.2899 | 0.75 | 3.00 |
PAH | phenylalanine hydroxylase | Hs.1870 | 2.43 | 4.54 |
HMGCS2 | 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial) | Hs.59889 | 2.17 | 4.24 |
PIPOX | pipecolic acid oxidase | Hs.271167 | −0.11 | 1.84 |
BPHL | biphenyl hydrolase-like (serine hydrolase) | Hs.351334 | 1.09 | 2.54 |
ASS | argininosuccinate synthetase | Hs.160786 | 1.60 | 3.03 |
Metabolism (carbohydrate) | ||||
GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | Hs.194710 | 2.71 | 1.21 |
FBP1 | fructose-1,6-bisphosphatase 1 | Hs.574 | 2.02 | 3.96 |
PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | Hs.75812 | 0.16 | 1.80 |
SORD | sorbitol dehydrogenase | Hs.878 | 1.00 | 2.37 |
Metabolism (lipid) | ||||
APOA4 | apolipoprotein A-IV | Hs.1247 | −2.39 | −3.57 |
CYP3A7 | cytochrome P450, subfamily IIIA, polypeptide 7 | Hs.172323 | 1.20 | 3.24 |
FABP1 | fatty acid binding protein 1, liver | Hs.380135 | 2.28 | 4.30 |
APOM | apolipoprotein M | Hs.247129 | 0.60 | 2.38 |
CYP3A4 | cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 | Hs.178738 | −0.52 | 1.23 |
APOH | apolipoprotein H (beta-2-glycoprotein I) | Hs.1252 | −3.31 | −1.73 |
Metabolism (general) | ||||
NNMT | nicotinamide N-methyltransferase | Hs.364345 | 0.83 | −1.41 |
AMACR | alpha-methylacyl-CoA racemase | Hs.128749 | 4.35 | 2.44 |
MAN1C1 | mannosidase, alpha, class 1C, member 1 | Hs.8910 | 2.24 | 0.72 |
RBP4 | retinol-binding protein 4, plasma | Hs.406268 | −3.11 | −0.78 |
ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | Hs.159608 | 1.20 | 3.02 |
PANK1 | pantothenate kinase 1 | Hs.116122 | 0.90 | 2.52 |
DHDH | dihydrodiol dehydrogenase (dimeric) | Hs.133083 | 1.52 | 3.07 |
ALDRL6 | aldehyde reductase (aldose reductase) like 6 | Hs.129227 | 0.98 | 2.33 |
Cell cycle/cell division/cell proliferation | ||||
RARRES3 | retinoic acid receptor responder (tazarotene induced) 3 | Hs.17466 | 4.90 | 2.08 |
HIF1A | hypoxia-inducible factor 1, alpha subunit | Hs.197540 | 1.44 | −0.80 |
STAT1 | signal transducer and activator of transcription 1, 91 kDa | Hs.21486 | 2.32 | 0.33 |
TIMP1 | tissue inhibitor of metalloproteinase 1 | Hs.433425 | −1.70 | −3.56 |
ADAMTS1 | a disintegrin-like and metalloprotease with thrombospondin t1 mot1 | Hs.8230 | 1.39 | −0.40 |
TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | Hs.83429 | 5.15 | 3.40 |
CDC25B | cell division cycle 25B | Hs.153752 | −0.86 | −2.53 |
RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | Hs.82547 | 2.28 | 0.86 |
RBPMS | RNA-binding protein gene with multiple splicing | Hs.80248 | 0.35 | −0.99 |
BIRC3 | baculoviral IAP repeat-containing 3 | Hs.127799 | 1.65 | 0.48 |
ATF3 | activating transcription factor 3 | Hs.460 | −0.69 | 1.10 |
EGF | epidermal growth factor (beta-urogastrone) | Hs.2230 | 3.33 | 4.95 |
MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | Hs.20555 | 1.64 | 2.98 |
Protein modification | ||||
SERPINA3 | serine proteinase inhibitor, clade A , member 3 | Hs.234726 | 1.19 | −3.39 |
SLPI | secretory leukocyte protease inhibitor (antileukoproteinase) | Hs.251754 | −0.13 | −1.84 |
QPCT | glutaminyl-peptide cyclotransferase (glutaminyl cyclase) | Hs.79033 | −1.76 | −3.43 |
SMPD1 | sphingomyelin phosphodiesterase 1, acid lysosomal | Hs.77813 | 1.63 | −0.03 |
STK19 | serine/threonine kinase 19 | Hs.444 | 1.91 | 0.32 |
SERPINE2 | serine proteinase inhibitor, clade E , member 2 | Hs.21858 | −2.24 | −3.73 |
PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 | Hs.180062 | 0.77 | −0.66 |
H11 | protein kinase H11 | Hs.111676 | 2.84 | 1.42 |
SERPING1 | serine proteinase inhibitor, clade G, member 1 | Hs.151242 | 3.38 | 2.08 |
PPP1R16B | protein phosphatase 1, regulatory (inhibitor) subunit 16B | Hs.45719 | 1.49 | 3.03 |
XPNPEP2 | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane bound | Hs.57922 | 3.67 | 5.11 |
Cytoskeleton | ||||
TUBA3 | tubulin, alpha 3 | Hs.433394 | −0.44 | −2.23 |
ARPC1B | actin-related protein 2/3 complex, subunit 1B, 41 kDa | Hs.11538 | −1.30 | −2.92 |
TMSB10 | thymosin, beta 10 | Hs.76293 | 0.06 | −1.38 |
SDC1 | syndecan 1 | Hs.82109 | 0.30 | 1.75 |
PLEC1 | plectin 1, intermediate filament binding protein 500 kDa | Hs.79706 | −0.61 | 0.82 |
Hemostasis | ||||
FGG | fibrinogen, gamma polypeptide | Hs.75431 | −0.14 | −1.61 |
PROZ | protein Z, vitamin K-dependent plasma glycoprotein | Hs.1011 | 1.90 | 3.65 |
PLG | plasminogen | Hs.75576 | 3.02 | 4.44 |
Others | ||||
REG1A | regenerating islet-derived 1 alpha | Hs.49407 | 2.76 | 0.00 |
GRP58 | glucose-regulated protein, 58 kDa | Hs.13751 | 1.74 | −0.59 |
CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | Hs.32963 | 4.58 | 2.49 |
SPP1 | secreted phosphoprotein 1 (osteopontin, bone sialoprotein I) | Hs.313 | 5.16 | 3.18 |
CARHSP1 | calcium-regulated heat-stable protein 1, 24 kDa | Hs.92198 | 0.36 | −1.60 |
CSPG2 | chondroitin sulfate proteoglycan 2 (versican) | Hs.81800 | −1.95 | −3.86 |
OSF-2 | osteoblast-specific factor 2 (fasciclin I-like) | Hs.136348 | 2.02 | 0.13 |
NPC1 | Niemann–Pick disease, type C1 | Hs.76918 | 0.76 | −1.01 |
DBI | diazepam-binding inhibitor (GABA receptor modulator) | Hs.78888 | 3.00 | 1.35 |
UGCG | UDP-glucose ceramide glucosyltransferase | Hs.432605 | 1.84 | 0.23 |
PCP4 | Purkinje cell protein 4 | Hs.80296 | 2.49 | 0.89 |
SLC39A1 | solute carrier family 39 (zinc transporter), member 1 | Hs.7854 | 0.68 | −0.85 |
FLOT1 | flotillin 1 | Hs.179986 | 0.19 | −1.33 |
GOLGIN-67 | golgin-67 | Hs.182982 | 2.65 | 1.20 |
CALML3 | calmodulin-like 3 | Hs.239600 | 0.39 | 2.64 |
CLCN4 | chloride channel 4 | Hs.199250 | 0.45 | 2.26 |
CTEN | C-terminal tensin-like | Hs.294022 | 0.55 | 2.25 |
EPHB1 | EphB1 | Hs.78436 | 0.04 | 1.73 |
