Table 1 Cytotoxic activity of CMCs derived from B6-+/+, B6-mi/mi, B6-Mior/Mior, B6-tg/tg, B6-mice/mice or B6-miew/miew mice

From: Strain-dependent inhibitory effect of mutant mi-MITF on cytotoxic activities of cultured mast cells and natural killer cells of mice

E/T ratio

Specific 51Cr release (%) by 18 h coculturea

 

B6-+/+

B6-mi/mi

B6-Mi or /Mi or

B6-tg/tg

B6-mi ce /mi ce

B6-mi ew /mi ew

50

3.5±1.9 (5)†

<0.1 (5)*

<0.1 (3)*

3.4±0.9 (4)†

3.1±0.2 (4)†

3.7±0.3 (4)†

100

14.1±1.8 (5)†

<0.1 (5)*

<0.1 (3)*

11.8±0.7 (4)*,†

12.4±1.2 (4)†

11.6±1.3 (4)†

250

23.4±1.3 (5)†

<0.1 (5)*

2.7±2.7 (3)*

18.1±0.9 (4)*,†

18.2±1.4 (4)*,†

18.4±0.9 (4)*,†

  1. E/T ratio indicates the ratio of CMCs to YAC-1 cells.
  2. aMean±s.e. The number of independent assays are shown within parentheses.
  3. *P<0.05 by t-test when compared with the value of B6-+/+ CMCs.
  4. †P<0.05 by t-test when compared with the value of B6-mi/mi CMCs.
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