Table 3 Cytotoxic activity of spleen mononuclear cells derived from B6-+/+, B6-mi/mi, B6-Mior/Mior, B6-tg/tg, B6-mice/mice or B6-miew/miew mice which received poly I:C injection

From: Strain-dependent inhibitory effect of mutant mi-MITF on cytotoxic activities of cultured mast cells and natural killer cells of mice

E/T ratio

Specific 51Cr release (%) by 4 h coculturea

 

B6-+/+

B6-mi/mi

B6-Mi or /Mi or

B6-tg/tg

B6-mi ice /mi ce

B6-mi ew /mi ew

10

9.2±0.9 (3)*

2.3±0.4 (3)†

1.8±0.3 (3)†

7.5±0.4 (3)*

10.8±1.2 (3)*

9.0±1.2 (3)*

40

26.3±1.3 (3)*

4.3±0.2 (3)†

3.8±0.7 (3)†

25.2±0.6 (3)*

24.2±1.0 (3)*

25.1±1.0 (3)*

75

40.7±1.3 (3)*

8.1±0.4 (3)†

7.8±1.0 (3)†

38.9±1.1 (3)*

39.5±1.1 (3)*

37.4±0.8 (3)*

  1. E/T ratio indicates the ratio of spleen mononuclear cells to YAC-1 cells.
  2. aMean±s.e. The number of independent assays are shown within parentheses.
  3. *P<0.05 by t test when compared with the value of spleen mononuclear cells of B6-mi/mi mice.
  4. †P<0.05 by t test when compared with the value of spleen mononuclear cells of B6-+/+ mice.
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