Table 4 Cytotoxic activity of spleen mononuclear cells derived from WB-+/+, WB-mi/mi, WBB6F1-+/+ or WBB6F1-mi/mi mice with or without poly I:C injection

From: Strain-dependent inhibitory effect of mutant mi-MITF on cytotoxic activities of cultured mast cells and natural killer cells of mice

Poly I:C injection

E/T ratio

Specific 51Cr release (%) by 4 h coculturea

  

WB-+/+

WB-mi/mi

WBB6F1-+/+

WBB6F 1 -mi/mi

No

10

7.9±0.7 (3)

10.2±2.9 (3)

8.3±1.3 (4)

7.5±0.2 (4)

 

40

17.0±1.5 (3)

21.8±3.1 (3)

16.5±1.1 (4)

16.3±1.1 (4)

 

75

31.4±2.1 (3)

37.8±3.1 (3)

32.5±0.5 (4)

30.4±1.8 (4)

Yes

10

16.6±5.6 (3)

13.6±3.8 (3)

16.7±2.3 (6)

14.6±3.2 (6)

 

40

30.3±3.3 (3)

30.8±4.3 (3)

30.6±1.4 (6)

27.4±1.6 (6)

 

75

52.1±2.5 (3)

47.9±5.8 (3)

52.5±1.3 (6)

47.2±1.4 (6)

  1. E/T ratio indicates the ratio of spleen mononuclear cells to YAC-1 cells.
  2. aMean±s.e. The number of independent assays are shown in parentheses. Significant difference (P<0.05 by t-test) was not detectable between values of +/+ and mi/mi mice of the same genetic background.
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