Table 5 Cytotoxic activity of spleen cells of B6-+/+, B6-mi/mi, WB-+/+, WB-mi/mi, WBB6F1-+/+ or WBB6F1-mi/mi mice cultured in the presence of mouse IL-2 and IL-18 for 7 days

From: Strain-dependent inhibitory effect of mutant mi-MITF on cytotoxic activities of cultured mast cells and natural killer cells of mice

E/T ratio

Specific 51Cr release (%) by 4 h coculturea

 

B6-+/+

B6-mi/mi

WB-+/+

WB-mi/mi

WBB6F1-+/+

WBB6F 1 -mi/mi

10

13.3±1.1 (3)

6.8±1.2 (3)*

12.2±0.8 (3)

11.0±0.9 (3)

14.8±1.1 (3)

11.9±1.2 (3)

40

30.6±1.6 (3)

10.6±1.0 (3)*

25.6±0.9 (3)

24.9±1.0 (3)

29.6±1.4 (3)

27.2±1.3 (3)

75

66.3±1.2 (3)

14.3±0.8 (3)*

62.9±0.9 (3)

61.7±1.2 (3)

68.4±1.4 (3)

66.3±1.3 (3)

  1. E/T ratio indicates the ratio of spleen mononuclear cells to YAC-1 cells.
  2. aMean±s.e. The number of independent assays are shown within parentheses.
  3. *P<0.05 by t-test when compared with the value of cultured spleen cells of +/+ mice of the same genetic background.
Back to article page